Author:
Sgourou Argyro,Fotopoulos Vassilis,Kontos Vassilis,Patrinos George P,Papachatzopoulou Adamantia
Abstract
Abstract
Background
The aim of this study was to determine the genotype distribution and allelic frequencies of ACE (I/D), AGTR1 (A +1166 C), BDKRB2 (+9/−9) and LEP (G–2548A) genomic variations in 175 Greek athletes who excelled at a national and/or international level and 169 healthy Greek adults to identify whether some particular combinations of these loci might serve as predictive markers for superior physical condition.
Results
The D/D genotype of the ACE gene (p = 0.034) combined with the simultaneous existence of BDKRB2 (+9/−9) (p = 0.001) or LEP (G/A) (p = 0.021) genotypes was the most prevalent among female athletes compared to female controls. A statistical trend was also observed in BDKRB2 (+9/−9) and LEP (G–2548A) heterozygous genotypes among male and female Greek athletes, and in ACE (I/D) only in male athletes. Finally, both male and female athletes showed the highest rates in the AGTR1 (A/A) genotype.
Conclusions
Our results suggest that the co-existence of ACE (D/D), BDKRB2 (+9/−9) or LEP (G/A) genotypes in female athletes might be correlated with a superior level of physical performance.
Publisher
Springer Science and Business Media LLC
Subject
Drug Discovery,Genetics,Molecular Biology,Molecular Medicine
Reference38 articles.
1. Rankinen T, Bray MS, Hagberg JM, Pérusse L, Roth SM, Wolfarth B, Bouchard C: The human gene map for performance and health-related fitness phenotypes: the 2005 update. Med Sci Sports Exerc. 2006, 38: 1863-1888. 10.1249/01.mss.0000233789.01164.4f.
2. Rigat B, Hubert C, Alhenc-Gelas F, Cambien F, Corvol P, Soubrier F: An insertion/deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest. 1990, 86: 1343-1356. 10.1172/JCI114844.
3. Puthucheary Z, Skipworth JR, Rawal J, Loosemore M, Van Someren K, Montgomery HE: The ACE gene and human performance: 12 years on. Sports Med. 2011, 41: 433-448. 10.2165/11588720-000000000-00000.
4. Guyton AC, Hall JE: Dominant role of the kidney in the long-term regulation of arterial pressure and in hypertension: the integrated system for pressure control. In Guyton & Hall: Textbook of Medical Physiology. 2000, Philadelphia: Saunders, 195-209. 10
5. Lavoie JL, Sigmund CD: Minireview: overview of the renin-angiotensin system–an endocrine and paracrine system. Endocrinology. 2003, 144: 2179-2183. 10.1210/en.2003-0150.
Cited by
6 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献