Time-differentiated target temperature management after out-of-hospital cardiac arrest: a multicentre, randomised, parallel-group, assessor-blinded clinical trial (the TTH48 trial): study protocol for a randomised controlled trial-Reference-Cited by-同舟云学术

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Time-differentiated target temperature management after out-of-hospital cardiac arrest: a multicentre, randomised, parallel-group, assessor-blinded clinical trial (the TTH48 trial): study protocol for a randomised controlled trial

Published:2016-05-04 Issue:1 Volume:17 Page:
ISSN:1745-6215
Container-title:Trials
language:en
Short-container-title:Trials

Author:

Kirkegaard Hans,Rasmussen Bodil S,de Haas Inge,Nielsen Jørgen Feldbæk,Ilkjær Susanne,Kaltoft Anne,Jeppesen Anni Nørregaard,Grejs Anders,Duez Christophe Henri Valdemar,Larsen Alf Inge,Pettilä Ville,Toome Valdo,Arus Urmet,Taccone Fabio Silvio,Storm Christian,Skrifvars Markus B.,Søreide Eldar

Funder

The Danish Heart Foundation (99,180 €)

Laerdal Foundation for Acute Medicine (31,100 €)

The Danish Society of Anaesthesiology and Intensive Care Medicine (6,700 €)

The Augustinus Foundation (67,000 €)

The Scandinavian Society of Anaesthesiology and Intensive Care Medicine (16,750 €)

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Medicine (miscellaneous)

Link

http://link.springer.com/content/pdf/10.1186/s13063-016-1338-9

Reference38 articles.

1. Neumar RW et al. Post-cardiac arrest syndrome: epidemiology, pathophysiology, treatment and prognostication, a concensus statement. Circulation. 2008;118:2452–83.

2. Lampe JW, Becker L. State of the art in therapeutic hypothermia. Annu Rev Med. 2011;62:11.1–11.15. doi: 10.1146/annurev-med-052009-150512 .

3. Hoesch RE, Koenig MA, Geocardin RG. Coma after global ischemic brain injury: pathophysiology and emerging therapies. Crit Care Clin. 2008;24:25–44.

4. Szydlowska K, Tymianski M. Calcium ischemia and excitotoxicity. Cell Calcium. 2010;47:122–9.

5. Crack PJ, Wong HY, Connie HY. Modulation of neuro-inflammation and vascular response by oxidative stress following cerebral ischemia-reperfusion injury. Curr Med Chem. 2008;15(1):1–14.

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1. Variability in Temperature Control Practices Amongst the Influence of Cooling duration on Efficacy in Cardiac Arrest Patients (ICECAP) trial;Resuscitation;2024-09

2. Neurofilament Light Chain and Glial Fibrillary Acidic Protein as early prognostic biomarkers after out-of-hospital cardiac arrest;Resuscitation;2023-12

3. Fibrinolysis in Cardiac Arrest Patients Treated with Hypothermia;Therapeutic Hypothermia and Temperature Management;2022-12-06

4. Kinetics of 2 different high-sensitive troponins during targeted temperature management in out-of-hospital cardiac arrest patients with acute myocardial infarction: a post hoc sub-study of a randomised clinical trial;BMC Cardiovascular Disorders;2022-07-30

5. Quantitative pupillometry in comatose out‐of‐hospital cardiac arrest patients: A post‐hoc analysis of the TTH48 trial;Acta Anaesthesiologica Scandinavica;2022-05-29

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