Abstract
Abstract
Background
As the population of Korea ages, interest in healthcare has increased. In particular, there is an increasing demand for immune-function improvement to prevent infectious diseases. Phellinus linteus (PL) has previously been shown to exert immune-enhancing and anticancer effects. We aim to evaluate whether PL mycelium extract, cultured from the PL KCTC0399BP strain, can increase immune function, as measured using blood-test indicators. This clinical trial protocol is designed as the main trial and is based on the results of a pilot study.
Methods
This clinical trial is a randomized, double-blinded, placebo-controlled trial. Ninety-eight participants are enrolled and randomly divided into two groups: the experimental group (PL 1000 mg) and the control group (placebo). Participants are administered with experimental food or placebo for eight weeks. Blood tests are performed before trial initiation and 8 weeks later, at trial completion. Laboratory evaluation items are as follows: natural killer cell activity, tumor necrosis factor-α, interferon-γ, interleukin (IL)-1β, IL-2, IL-6, IL-12, immunoglobulin (Ig)G1, IgG2, and IgM. We will mainly use the full analysis dataset to statistically analyze the effectiveness of the treatment.
Discussion
This study evaluates the effects of PL extract on immune function and will contribute to knowledge on the value of PL as an immune-function–boosting functional food.
Trial registration
Clinical Research Information Service (CRIS) of Korea CRIS-KCT0005460. Registered on 12 October 2020
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Medicine (miscellaneous)
Reference17 articles.
1. Galanakis CM, Aldawoud TMS, Rizou M, Rowan NJ, Ibrahim SA. Food ingredients and active compounds against the coronavirus disease (COVID-19) pandemic: a comprehensive review. Foods. 2020;9(11):1701. https://doi.org/10.3390/foods9111701.
2. Kim GY, Oh WK, Shin BC, Shin YO, Park YC, Ahn SC, et al. Proteoglycan isolated from Phellinus linteus inhibits tumor growth through mechanisms leading to an activation of CD11c + CD8+ DC and type I helper T cell-dominant immune state. FEBS Lett. 2004;76(3):391–400. https://doi.org/10.1016/j.febslet.2004.09.047.
3. Eom SY, Zhang YW, Kim NS, Kang JW, Hahn YS, Shin KS, et al. Effects of Keumsa Sangwhang (Phellinus linteus) mushroom extracts on the natural killer cell activity in human. Korean J Food Sci Technol. 2006;38(5):717–9.
4. Kim HM, Han SB, Oh GT, Kim YH, Hong DH, Hong ND, et al. Stimulation of humoral and cell mediated immunity by polysaccharide from mushroom Phellinus linteus. Int J Immunopharmacol. 1996;18(5):295–303. https://doi.org/10.1016/0192-0561(96)00028-8.
5. Lee JW, Back SJ, Bae WC, Park JM, Kim YS. Antitumor and antioxidant activities of the extracts from fruiting body of Phellinus linteus. Mycobiology. 2006;34(4):230–5. https://doi.org/10.4489/MYCO.2006.34.4.230.
Cited by
3 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献