General practitioner use of a C-reactive protein point-of-care test to help target antibiotic prescribing in patients with acute exacerbations of chronic obstructive pulmonary disease (the PACE study): study protocol for a randomised controlled trial

Author:

Bates JanineORCID,Francis Nick A.,White Patrick,Gillespie David,Thomas-Jones Emma,Breen Rachel,Kirby Nigel,Hood Kerry,Gal Micaela,Phillips Rhiannon,Naik Gurudutt,Cals Jochen,Llor Carl,Melbye Hasse,Wootton Mandy,Riga Evgenia,Cochrane Ann,Howe Robin,Fitzsimmons Deborah,Sewell Bernadette,Alam Mohammed Fasihul,Butler Christopher C.

Funder

Health Technology Assessment Programme

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Medicine (miscellaneous)

Reference47 articles.

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2. Horvath AR, Lord SJ, StJohn A, Sandberg S, Cobbaert CM, Lorenz S, et al. From biomarkers to medical tests: the changing landscape of test evaluation. Clin Chim Acta. 2014;427:49–57.

3. Food and Drug Administration. Medical devices: overview of IVD regulation. Available from: https://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/IVDRegulatoryAssistance/ucm123682.htm . Accessed 07 Sept 2017.

4. Ferrante Di Ruffano L, Hyde CJ, McCaffery KJ, Bossuyt PMM, Deeks JJ. Assessing the value of diagnostic tests: a framework for designing and evaluating trials. BMJ (Online). 2012;344(7847), e686.

5. Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis. BMJ (Online). 2010;340(7756):1120.

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