A multi-centre, pragmatic, three-arm, individually randomised, non-inferiority, open trial to compare immediate orally administered, immediate topically administered or delayed orally administered antibiotics for acute otitis media with discharge in children: The Runny Ear Study (REST): study protocol-Reference-Cited by-同舟云学术

A multi-centre, pragmatic, three-arm, individually randomised, non-inferiority, open trial to compare immediate orally administered, immediate topically administered or delayed orally administered antibiotics for acute otitis media with discharge in children: The Runny Ear Study (REST): study protocol

Published:2020-06-03 Issue:1 Volume:21 Page:
ISSN:1745-6215
Container-title:Trials
language:en
Short-container-title:Trials

Author:

Curtis Kathryn,Moore Michael,Cabral Christie,Curcin Vasa,Horwood Jeremey,Morris Richard,Prasad Vibhore,Schilder Anne,Turner Nicholas,Wilkes Scott,Hay Alastair D.,Taylor Jodi^ORCID

Funder

Health Technology Assessment Programme

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Medicine (miscellaneous)

Link

http://link.springer.com/content/pdf/10.1186/s13063-020-04419-7.pdf

Reference30 articles.

1. Little P, Gould C, Williamson I, et al. Pragmatic randomised controlled trial of two prescribing strategies for childhood acute otitis media. BMJ. 2001;322(7282):336–42.

2. Smith L, Ewings P, Smith C, et al. Ear discharge in children presenting with acute otitis media: observational study from UK general practice. Br J Gen Pract. 2010;60(571):101–5. https://doi.org/10.3399/bjgp10X483148 .

3. Rovers MM, Glasziou P, Appelman CL, et al. Antibiotics for acute otitis media: a meta-analysis with individual patient data. Lancet. 2006;368(9545):1429–35.