GRam stain-guided Antibiotics ChoicE for Ventilator-Associated Pneumonia (GRACE-VAP) trial: rationale and study protocol for a randomised controlled trial

Author:

Yoshimura Jumpei,Yamakawa KazumaORCID,Kinoshita Takahiro,Ohta Yoshinori,Morimoto Takeshi

Funder

Osaka General Medical Center

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Medicine (miscellaneous)

Reference21 articles.

1. Llor C, Bjerrum L. Antimicrobial resistance: risk associated with antibiotic overuse and initiatives to reduce the problem. Ther Adv Drug Saf. 2014;5:229–41.

2. World Health Organisation (WHO). Antimicrobial resistance: global report on surveillance. 2014. http://apps.who.int/iris/bitstream/10665/112642/1/9789241564748_eng.pdf . Accessed 24 Oct 2018.

3. Wenzel RP. The antibiotic pipeline—challenges, costs, and values. N Engl J Med. 2004;351:523–6.

4. Cassell GH, Mekalanos J. Development of antimicrobial agents in the era of new and reemerging infectious diseases and increasing antibiotic resistance. JAMA. 2001;285:601–5.

5. World Health Organisation (WHO). Global action plan on antimicrobial resistance. 2015. http://apps.who.int/iris/bitstream/10665/193736/1/9789241509763_eng.pdf . Accessed 24 Oct 2018.

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