A multi-centre, double-blind, placebo-controlled, randomised trial of combination methotrexate and gefitinib versus methotrexate alone to treat tubal ectopic pregnancies (GEM3): trial protocol

Author:

May James,Duncan Colin,Mol Ben,Bhattacharya Siladitya,Daniels Jane,Middleton Lee,Hewitt Catherine,Coomarasamy Arri,Jurkovic Davor,Bourne Tom,Bottomley Cecilia,Peace-Gadsby Alexandra,Doust Ann,Tong Stephen,Horne Andrew W.

Funder

Efficacy and Mechanism Evaluation Programme

Publisher

Springer Science and Business Media LLC

Subject

Pharmacology (medical),Medicine (miscellaneous)

Reference16 articles.

1. Cantwell R, Clutton-Brock T, Cooper G, Dawson A, Drife J, Garrod D, Harper A, Hulbert D, Lucas S, McClure J, et al. Saving mothers' lives: reviewing maternal deaths to make motherhood safer: 2006-2008. The eighth report of the confidential enquiries into maternal deaths in the United Kingdom. BJOG. 2011;118(Suppl 1):1–203.

2. Say L, Chou D, Gemmill A, Tuncalp O, Moller AB, Daniels J, Gulmezoglu AM, Temmerman M, Alkema L. Global causes of maternal death: a WHO systematic analysis. Lancet Glob Health. 2014;2(6):e323–33.

3. Ectopic pregnancy and miscarriage: diagnosis and initial management in early pregnancy for ectopic pregnancy and miscarriage (clinical guideline 154) [ http://www.nice.org.uk/CG154 ]. Accessed 12 Nov 2018.

4. Mavrelos D, Nicks H, Jamil A, Hoo W, Jauniaux E, Jurkovic D. Efficacy and safety of a clinical protocol for expectant management of selected women diagnosed with a tubal ectopic pregnancy. Ultrasound Obstet Gynecol. 2013;42(1):102–7.

5. van Mello NM, Mol F, Verhoeve HR, van Wely M, Adriaanse AH, Boss EA, Dijkman AB, Bayram N, Emanuel MH, Friederich J, et al. Methotrexate or expectant management in women with an ectopic pregnancy or pregnancy of unknown location and low serum hCG concentrations? A randomized comparison. Hum Reprod. 2013;28(1):60–7.

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