Author:
Gao Zhen,Yin Tao,Lan Lei,Li Dehua,Sun Ruirui,Ha Guodong,Jiang Caili,Shao Xin,He Zhaoxuan,Ji Laixi,Zeng Fang
Abstract
Abstract
Background
Acupuncture is effective for reducing the symptoms of neck pain (NP). However, the underlying mechanisms are not fully elucidated. Based on evaluating the efficacy of two acupuncture prescriptions for treating NP, this study aims to investigate the potential central mechanism of acupuncture treatment for NP by functional magnetic resonance imaging (fMRI).
Methods
This is a randomized controlled trial; 86 patients will be randomly assigned into two acupuncture treatment groups at a ratio of 1:1. The whole study period includes 2 weeks baseline, 2 weeks treatments, and 12 weeks follow-up (4 and 12 weeks after treatment). The pain severity, the neck disability index, the cervical range of motion, and the pressure pain threshold, etc., will be used to evaluate the clinical efficacy of two acupuncture prescriptions for NP treatment. The MRI scans will be performed to detect cerebral activity changes of 20 patients in each group. The clinical data and MRI data will be analyzed, respectively. Pearson correlation coefficient will be used to evaluate the association between changes of cerebral activity features and improvement of clinical symptoms.
Discussion
The results will provide further evidence for the clinical application of acupuncture in the treatment of NP.
Trial registration
Chinese Clinical Trial Registry ChiCTR2000040930. Registered on 16 December 2020.
Funder
the National Key Research and Development Program in China
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Medicine (miscellaneous)
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