Evaluating the effects of the novel GLP-1 analogue liraglutide in Alzheimer’s disease: study protocol for a randomised controlled trial (ELAD study)
Author:
Femminella Grazia Daniela, Frangou Eleni, Love Sharon B., Busza Gail, Holmes Clive, Ritchie Craig, Lawrence Robert, McFarlane Brady, Tadros George, Ridha Basil H., Bannister Carol, Walker Zuzana, Archer Hilary, Coulthard Elizabeth, Underwood Ben R., Prasanna Aparna, Koranteng Paul, Karim Salman, Junaid Kehinde, McGuinness Bernadette, Nilforooshan Ramin, Macharouthu Ajay, Donaldson Andrew, Thacker Simon, Russell Gregor, Malik Naghma, Mate Vandana, Knight Lucy, Kshemendran Sajeev, Harrison John, Brooks David J., Passmore Anthony Peter, Ballard Clive, Edison PaulORCID
Funder
Alzheimer's Society Alzheimer's Drug Discovery Foundation Van Geest Foundation Novo Nordisk UK Research Foundation
Publisher
Springer Science and Business Media LLC
Subject
Pharmacology (medical),Medicine (miscellaneous)
Reference50 articles.
1. Prince M, Wimo A, Guerchet M, Ali G, Wu Y, Prina M: World Alzheimer Report 2015—the global impact of dementia: an analysis of prevalence, incidence, cost and trends. 2015. Google Scholar 2017. 2. Cummings JL, Morstorf T, Zhong K. Alzheimer’s disease drug-development pipeline: few candidates, frequent failures. Alzheimers Res Ther. 2014;6(4):37. 3. Qi L, Ke L, Liu X, Liao L, Ke S, Liu X, Wang Y, Lin X, Zhou Y, Wu L, et al. Subcutaneous administration of liraglutide ameliorates learning and memory impairment by modulating tau hyperphosphorylation via the glycogen synthase kinase-3beta pathway in an amyloid beta protein induced alzheimer disease mouse model. Eur J Pharmacol. 2016;783:23–32. 4. Gejl M, Gjedde A, Egefjord L, Moller A, Hansen SB, Vang K, Rodell A, Braendgaard H, Gottrup H, Schacht A, et al. In Alzheimer’s disease, 6-month treatment with GLP-1 analog prevents decline of brain glucose metabolism: randomized, placebo-controlled, double-blind clinical trial. Front Aging Neurosci. 2016;8:108. 5. Schrijvers EM, Witteman JC, Sijbrands EJ, Hofman A, Koudstaal PJ, Breteler MM. Insulin metabolism and the risk of Alzheimer disease: the Rotterdam study. Neurology. 2010;75(22):1982–7.
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133 articles.
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