Prevalence of overweight/obesity and its relationship with metabolic syndrome and fatty liver index in adult patients with type 1 diabetes. A Brazilian multicenter study-Reference-Cited by-同舟云学术

Prevalence of overweight/obesity and its relationship with metabolic syndrome and fatty liver index in adult patients with type 1 diabetes. A Brazilian multicenter study

Published:2023-02-23 Issue:1 Volume:15 Page:
ISSN:1758-5996
Container-title:Diabetology & Metabolic Syndrome
language:en
Short-container-title:Diabetol Metab Syndr

Author:

Gomes Marilia Brito,Santos Deborah Conte,Drummond Karla,Pinheiro André,Muniz Luiza Harcar,Leal Franz,Negrato Carlos Antonio,Melo Laura Nunes,Cobas Roberta,Tannus Lucianne Righeti Monteiro,Rodacki Melanie,Zajdenverg Lenita,Dantas Joana Rodrigues,Corrêa-Giannella Maria Lúcia Cardillo,Admoni Sharon Nina,Santos Daniele Pereirados,Guedes Mariade Fatima,Dib Sergio Atala,Filho Celso Ferreirde Camargo Sallum,Pavin Elisabeth João,Takano Caroline,Rea Rosângela Roginski,Romanzini Nicole Balster,Azevedo Mirela,Canani Luis Henrique,Pedrosa Hermelinda Cordeiro,Tolentino Monica,Aguiar Cejana Hamu,Fonseca Reine Marie Chaves,Fonseca Ludmila Chaves,Kasprowicz Raffaele,Forti Adriana Costa e,Mendes Angela Delmira Nunes,Junior Renan Montenegro,Fernandes Virgínia Oliveira,Felício João Soares,Santos Flavia Marques,

Abstract

Abstract Aims To determine the prevalence of overweight/obesity and its relationship with metabolic syndrome (MS), fatty liver index (FLI), cardiovascular risk factors (CVRF), and diabetes-related chronic complications (DRCC) in adult patients with type 1 diabetes (T1D). Methods This study was conducted in 14 Brazilian public clinics in ten cities, with 1,390 patients: 802 females (57.7%), 779 (56.0%) Caucasians, aged 33.6 ± 10.8 years, age at diagnosis, 16.2 ± 9.2 years, diabetes duration, 17.4 ± 9.2 years, and HbA1c 8.8 ± 2.0%. Results Overall, 825 patients (59.4%) had normal weight, and 565 had overweight/obesity; ( 429 (30.9%) presented overweight and 136 (9.8%) presented obesity). After adjustments, overweight/obesity was associated with age, family history of overweight/obesity, total daily insulin dose, hypertension, adherence to diet, type of health care insurance, use of metformin, levels of C-reactive protein, triglycerides, uric acid and HDL-cholesterol. These patients also presented a higher prevalence of MS, FLI ≥ 60, and CVRF than patients without overweight/obesity. Overweight/obesity was not associated with DRCC and with HbA1c levels. Conclusions Patients with T1D with overweight/obesity presented traditional risk factors for DRCC, cardiovascular diseases, MS, and non-alcoholic fatty liver disease; most of these risk factors are modifiable and can be avoided with interventions that prevent overweight/obesity.

Publisher

Springer Science and Business Media LLC

Subject

Endocrinology, Diabetes and Metabolism,Internal Medicine

Link

https://link.springer.com/content/pdf/10.1186/s13098-023-00996-0.pdf

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