Author:
Cui Haozhe,Liu Qian,Zhao Zhiming,Ma Xiangming
Abstract
Abstract
Aims
The triglyceride-glucose (TyG) index and hypertension (HTN) are established risk factors of CVD. However, there is a dearth of studies investigating the synergistic influence of the elevated TyG index and HTN on CVD risk, as well as any potential interaction between these factors.
Method
For this investigation, we enlisted 88,384 individuals from the Kailuan Study who did not have a history of stroke, myocardial infarction, or cancer at baseline. Incidences of CVD between 2006 and 2021 were confirmed through a thorough review of medical records. Participants were categorized into 6 groups according to BP status(normal/elevated BP, stage 1 and stage 2) or the TyG index(low and elevated group), respectively. The Cox proportional hazard regression models were used to assess the association of BP status and TyG index with incident CVD. The multiplicative and additive interactions were also determined.
Results
Following a mean follow-up period of 13.66 ± 3.24 years, incidents of CVD, MI, and stroke were observed in 8,205, 1,728, and 6,705 individuals, respectively. The BP category and TyG index additively increased the risk of CVD, MI and stroke. There were significant interacting and joint effects of TyG index and BP status on CVD risk. Additionally, stratification analysis further confirmed that the relative contribution of hypertension to the CVD development decreased with deteriorating TyG index and that of TyG index was attenuated with increasing BP status.
Conclusion
Our study demonstrated that a significant interaction between TyG index and BP status on the risk of CVD.
Publisher
Springer Science and Business Media LLC
Reference26 articles.
1. Leong PJD, McKee M, et al. Reducing the Global Burden of Cardiovascular Disease, Part 1: the epidemiology and risk factors. Circul Res. 2017;121(6):677–94.
2. Gregory A, Roth GA, Mensah, Catherine O, Johnson et al. Global Burden of Cardiovascular diseases and Risk factors, 1990–2019: Update from the GBD 2019 study. J Am Coll Cardiol 2020 12 22;76(25):2982–3021.
3. Global Cardiovascular Risk Consortium, Magnussen C, Francisco M, Ojeda et al. Global Effect of Modifiable Risk Factors on Cardiovascular Disease and Mortality. The New England journal of medicine 2023 Aug 26.
4. Xin D, Patel A, Craig S, Anderson et al. Epidemiology of Cardiovascular Disease in China and opportunities for Improvement: JACC International. J Am Coll Cardiol 2019 06 25;73(24):3135–47.
5. Dong Zhao J, Liu M, Wang, et al. Epidemiology of cardiovascular disease in China: current features and implications. Nat Rev Cardiol. 2019;04(4):203–12.