Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7-Reference-Cited by-同舟云学术

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Design, synthesis and evaluation in an LPS rodent model of neuroinflammation of a novel 18F-labelled PET tracer targeting P2X7

Published:2017-04-04 Issue:1 Volume:7 Page:
ISSN:2191-219X
Container-title:EJNMMI Research
language:en
Short-container-title:EJNMMI Res

Author:

Fantoni Enrico Raffaele,Dal Ben Diego,Falzoni Simonetta,Di Virgilio Francesco,Lovestone Simon,Gee Antony

Funder

National Institute for Health Research

Wellcome Trust

Publisher

Springer Science and Business Media LLC

Subject

Radiology, Nuclear Medicine and imaging

Link

http://link.springer.com/content/pdf/10.1186/s13550-017-0275-2.pdf

Reference46 articles.

1. Sperlágh B, Illes P. P2X7 receptor: an emerging target in central nervous system diseases. Trends Pharmacol Sci. 2014;35(10):537–47.

2. Sanz JM, Chiozzi P, Ferrari D, Colaianna M, Idzko M, Falzoni S, et al. Activation of microglia by amyloid-beta requires P2X7 receptor expression. J Immunol. 2009;182(7):4378–85.

3. Chessell IP, Hatcher JP, Bountra C, Michel AD, Hughes JP, Green P, et al. Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain. Pain. 2005;114(3):386–96.

4. Clark AK, Wodarski R, Guida F, Sasso O, Malcangio M. Cathepsin S release from primary cultured microglia is regulated by the P2X7 receptor. Glia. 2010;58(14):1710–26.

5. Janssen B, Vugts DJ, Funke U, Spaans A, Schuit RC, Kooijman E, et al. Synthesis and initial preclinical evaluation of the P2X7 receptor antagonist [11C]A-740003 as a novel tracer of neuroinflammation. J Label Compd Radiopharm. 2014;57(8):509–16.

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