Therapeutic efficacy of α-radioimmunotherapy with different activity levels of the 213Bi-labeled monoclonal antibody MX35 in an ovarian cancer model

Author:

Gustafsson-Lutz Anna,Bäck Tom,Aneheim Emma,Hultborn Ragnar,Palm Stig,Jacobsson Lars,Morgenstern Alfred,Bruchertseifer Frank,Albertsson Per,Lindegren StureORCID

Funder

Cancerfonden (SE)

Vetenskapsrådet

Gustaf V Jubilee Clinic Cancer Research Foundation

Publisher

Springer Science and Business Media LLC

Subject

Radiology Nuclear Medicine and imaging

Reference25 articles.

1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015;65:87–108. doi: 10.3322/caac.21262 .

2. Elgqvist J, Andersson H, Back T, Claesson I, Hultborn R, Jensen H, et al. Alpha-radioimmunotherapy of intraperitoneally growing OVCAR-3 tumors of variable dimensions: outcome related to measured tumor size and mean absorbed dose. Journal of Nuclear Medicine. 2006;47:1342–50.

3. Elgqvist J, Andersson H, Back T, Claesson I, Hultborn R, Jensen H, et al. Fractionated radio immunotherapy of intraperitoneally growing ovarian cancer in nude mice with At-211-MX35 F(ab ’)(2): therapeutic efficacy and myelotoxicity. Nucl Med Biol. 2006;33:1065–72. doi: 10.1016/j.nucmedbio.2006.07.009 .

4. Elgqvist J, Andersson H, Back T, Hultborn R, Jensen H, Karlsson B, et al. Therapeutic efficacy and tumor dose estimations in radioimmunotherapy of intraperitoneally growing OVCAR-3 cells in nude mice with (211)At-labeled monoclonal antibody MX35. J Nucl Med. 2005;46:1907–15.

5. Elgqvist J, Andersson H, Bernhardt P, Back T, Claesson I, Hultborn R, et al. Administered activity and metastatic cure probability during radioimmunotherapy of ovarian cancer in nude mice with 211At-MX35 F(ab’)2. Int J Radiat Oncol Biol Phys. 2006;66:1228–37. doi: 10.1016/j.ijrobp.2006.07.003 .

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