Comparative binding properties of the tau PET tracers THK5117, THK5351, PBB3, and T807 in postmortem Alzheimer brains

Author:

Lemoine Laetitia,Gillberg Per-Göran,Svedberg Marie,Stepanov Vladimir,Jia Zhisheng,Huang Jinghai,Nag Sangram,Tian He,Ghetti Bernardino,Okamura Nobuyuki,Higuchi Makoto,Halldin Christer,Nordberg Agneta

Funder

Stiftelsen för Strategisk Forskning

swedish research council

stockholm county council karolinska institutet regional agreement on medical training and clinical research (ALF grant)

Swedish brain foundation

alzheimer foundation in sweden

EU FP7 large-scale integrating project INMind

the foundation for Old Servants

gun och bertil stohne's foundation

gunvor och josef anérs stiftelsen

Loo och Hans Ostermans Stiftelse för Medicinsk Forskning (SE)

Tore Nilsons Stiftelse för Medicinsk Forskning (SE)

ki foundation for geriatric diseases

gamla tjänarinnor stiftelsen

demensfonden stiftelsen

Publisher

Springer Science and Business Media LLC

Subject

Cognitive Neuroscience,Clinical Neurology,Neurology

Reference33 articles.

1. Shoghi-Jadid K, Small GW, Agdeppa ED, Kepe V, Ercoli LM, Siddarth P, Read S, Satyamurthy N, Petric A, Huang SC, et al. Localization of neurofibrillary tangles and β-amyloid plaques in the brains of living patients with Alzheimer disease. Am J Geriatr Psychiatry. 2002;10(1):24–35.

2. Thompson PW, Ye L, Morgenstern JL, Sue L, Beach TG, Judd DJ, Shipley NJ, Libri V, Lockhart A. Interaction of the amyloid imaging tracer FDDNP with hallmark Alzheimer’s disease pathologies. J Neurochem. 2009;109(2):623–30. doi: 10.1111/j.1471-4159.2009.05996.x .

3. Agdeppa ED, Kepe V, Liu J, Flores-Torres S, Satyamurthy N, Petric A, Cole GM, Small GW, Huang SC, Barrio JR. Binding characteristics of radiofluorinated 6-dialkylamino-2-naphthylethylidene derivatives as positron emission tomography imaging probes for β-amyloid plaques in Alzheimer’s disease. J Neurosci. 2001;21(24):RC189. https://www.ncbi.nlm.nih.gov/pubmed/11734604 .

4. Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, et al. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. 2013;79(6):1094–108. doi: 10.1016/j.neuron.2013.07.037 .

5. Velasco A, Fraser G, Delobel P, Ghetti B, Lavenir I, Goedert M. Detection of filamentous tau inclusions by the fluorescent Congo red derivative FSB [(trans, trans)-1-fluoro-2,5-bis(3-hydroxycarbonyl-4-hydroxy)styrylbenzene]. FEBS Lett. 2008;582(6):901–6. doi: 10.1016/j.febslet.2008.02.025 .

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