Author:
Zhang Dan-Dan,Ou Ya-Nan,Yang Liu,Ma Ya-Hui,Tan Lan,Feng Jian-Feng,Cheng Wei,Yu Jin-Tai
Abstract
Abstract
Background
Previous studies found that cancer survivors had a reduced risk of dementia compared with the general population. However, these findings were uncertain because of survivor bias and a lack of stratification by cancer types. This current cohort study used data from the UK Biobank to explore these associations.
Methods
Multivariable Cox regression analyses were used to examine the association of cancer status and the risk of dementia with its subtypes after adjusting for age and sex. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated as a measure of relative risk by comparing observed dementia incidence among cancer patients.
Results
We included 263,151 participants in the observational analysis. During a median follow-up of 9.18 years, dementia was diagnosed in 472 individuals with cancer and 3685 individuals without cancer, respectively. Cancer patients had lower risks of dementia (hazard ratio: 0.89, confidence interval: 0.81–0.98) and its subtypes (Alzheimer’s disease [AD]: 0.85 [0.74–0.98]; vascular dementia [VD]: 0.81 [0.66–0.99]) in the Cox regression adjusted for age and sex. Individuals with cancers in the male genital system had substantially reduced risks of dementia (0.66 [0.46–0.93]) and AD (0.53 [0.29–0.97]) than those with cancers in other systems. Moreover, non-melanoma skin cancer and prostate cancer were associated with a reduced risk of dementia (0.79 [0.62–0.99]; 0.69 [0.49–0.97]), but not with AD or VD (P>0.05).
Conclusions
The current study supported a negative association between cancer and dementia risk, and encourages further exploration of the mechanistic basis of this inverse relationship to improve understanding.
Funder
National Natural Science Foundation of China
Shanghai Rising Star Program
Shanghai Municipal Science and Technology Major Project
Research Start-up Fund of Huashan Hospital
Excellence 2025 Talent Cultivation Program at Fudan University
ZHANGJIANG LAB
Tianqiao and Chrissy Chen Institute
the State Key Laboratory of Neurobiology and Frontiers Center for Brain Science of Ministry of Education, Fudan University
Publisher
Springer Science and Business Media LLC
Subject
Cognitive Neuroscience,Neurology (clinical),Neurology
Cited by
9 articles.
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