Diagnostic accuracy of research criteria for prodromal frontotemporal dementia

Author:

Benussi Alberto,Premi Enrico,Grassi Mario,Alberici Antonella,Cantoni Valentina,Gazzina Stefano,Archetti Silvana,Gasparotti Roberto,Fumagalli Giorgio G.,Bouzigues Arabella,Russell Lucy L.,Samra Kiran,Cash David M.,Bocchetta Martina,Todd Emily G.,Convery Rhian S.,Swift Imogen,Sogorb-Esteve Aitana,Heller Carolin,van Swieten John C.,Jiskoot Lize C.,Seelaar Harro,Sanchez-Valle Raquel,Moreno Fermin,Laforce Robert,Graff Caroline,Synofzik Matthis,Galimberti Daniela,Rowe James B.,Masellis Mario,Tartaglia Maria Carmela,Finger Elizabeth,Vandenberghe Rik,Mendonça Alexandre,Tiraboschi Pietro,Butler Chris R.,Santana Isabel,Gerhard Alexander,Le Ber Isabelle,Pasquier Florence,Ducharme Simon,Levin Johannes,Sorbi Sandro,Otto Markus,Padovani Alessandro,Rohrer Jonathan D.,Borroni Barbara, ,Nelson Annabel,Bocchetta Martina,Thomas David L.,Benotmane Hanya,Nicholas Jennifer,Shafei Rachelle,Timberlake Carolyn,Cope Thomas,Rittman Timothy,Arighi Andrea,Fenoglio Chiara,Scarpini Elio,Borracci Vittoria,Rossi Giacomina,Giaccone Giorgio,Di Fede Giuseppe,Caroppo Paola,Prioni Sara,Redaelli Veronica,Tang-Wai David,Rogaeva Ekaterina,Castelo-Branco Miguel,Freedman Morris,Keren Ron,Black Sandra,Mitchell Sara,Shoesmith Christen,Bartha Robart,Rademakers Rosa,Poos Jackie,Papma Janne M.,Giannini Lucia,van Minkelen Rick,Pijnenburg Yolande,Nacmias Benedetta,Ferrari Camilla,Polito Cristina,Lombardi Gemma,Bessi Valentina,Veldsman Michele,Andersson Christin,Thonberg Hakan,Öijerstedt Linn,Jelic Vesna,Thompson Paul,Langheinrich Tobias,Lladó Albert,Antonell Anna,Olives Jaume,Balasa Mircea,Bargalló Nuria,Borrego-Ecija Sergi,Verdelho Ana,Maruta Carolina,Ferreira Catarina B.,Miltenberger Gabriel,do Couto Frederico Simões,Gabilondo Alazne,Gorostidi Ana,Villanua Jorge,Cañada Marta,Tainta Mikel,Zulaica Miren,Barandiaran Myriam,Alves Patricia,Bender Benjamin,Wilke Carlo,Graf Lisa,Vogels Annick,Vandenbulcke Mathieu,Van Damme Philip,Bruffaerts Rose,Poesen Koen,Rosa-Neto Pedro,Gauthier Serge,Camuzat Agnès,Brice Alexis,Bertrand Anne,Funkiewiez Aurélie,Rinaldi Daisy,Saracino Dario,Colliot Olivier,Sayah Sabrina,Prix Catharina,Wlasich Elisabeth,Wagemann Olivia,Loosli Sandra,Schönecker Sonja,Hoegen Tobias,Lombardi Jolina,Anderl-Straub Sarah,Rollin Adeline,Kuchcinski Gregory,Bertoux Maxime,Lebouvier Thibaud,Deramecourt Vincent,Santiago Beatriz,Duro Diana,Leitão Maria João,Almeida Maria Rosario,Tábuas-Pereira Miguel,Afonso Sónia

Abstract

Abstract Background The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment (MCBMI). The objective of the study was to validate the proposed research criteria for MCBMI-FTD in a cohort of genetically confirmed FTD cases against healthy controls. Methods A total of 398 participants were enrolled, 117 of whom were carriers of an FTD pathogenic variant with mild clinical symptoms, while 281 were non-carrier family members (healthy controls (HC)). A subgroup of patients underwent blood neurofilament light (NfL) levels and anterior cingulate atrophy assessment. Results The core clinical criteria correctly classified MCBMI vs HC with an AUC of 0.79 (p < 0.001), while the addition of either blood NfL or anterior cingulate atrophy significantly increased the AUC to 0.84 and 0.82, respectively (p < 0.001). The addition of both markers further increased the AUC to 0.90 (p < 0.001). Conclusions The proposed MCBMI criteria showed very good classification accuracy for identifying the prodromal stage of FTD.

Publisher

Springer Science and Business Media LLC

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3