Subclinical epileptiform discharges in Alzheimer’s disease are associated with increased hippocampal blood flow-Reference-Cited by-同舟云学术

Subclinical epileptiform discharges in Alzheimer’s disease are associated with increased hippocampal blood flow

Published:2024-04-12 Issue:1 Volume:16 Page:
ISSN:1758-9193
Container-title:Alzheimer's Research & Therapy
language:en
Short-container-title:Alz Res Therapy

Author:

Musaeus Christian Sandøe,Kjaer Troels Wesenberg,Lindberg Ulrich,Vestergaard Mark B.,Bo Henrik,Larsson Wiberg,Press Daniel Zvi,Andersen Birgitte Bo,Høgh Peter,Kidmose Preben,Hemmsen Martin Christian,Rank Mike Lind,Hasselbalch Steen Gregers,Waldemar Gunhild,Frederiksen Kristian Steen

Abstract

Abstract Background In epilepsy, the ictal phase leads to cerebral hyperperfusion while hypoperfusion is present in the interictal phases. Patients with Alzheimer’s disease (AD) have an increased prevalence of epileptiform discharges and a study using intracranial electrodes have shown that these are very frequent in the hippocampus. However, it is not known whether there is an association between hippocampal hyperexcitability and regional cerebral blood flow (rCBF). The objective of the study was to investigate the association between rCBF in hippocampus and epileptiform discharges as measured with ear-EEG in patients with Alzheimer’s disease. Our hypothesis was that increased spike frequency may be associated with increased rCBF in hippocampus. Methods A total of 24 patients with AD, and 15 HC were included in the analysis. Using linear regression, we investigated the association between rCBF as measured with arterial spin-labelling MRI (ASL-MRI) in the hippocampus and the number of spikes/sharp waves per 24 h as assessed by ear-EEG. Results No significant difference in hippocampal rCBF was found between AD and HC (p-value = 0.367). A significant linear association between spike frequency and normalized rCBF in the hippocampus was found for patients with AD (estimate: 0.109, t-value = 4.03, p-value < 0.001). Changes in areas that typically show group differences (temporal-parietal cortex) were found in patients with AD, compared to HC. Conclusions Increased spike frequency was accompanied by a hemodynamic response of increased blood flow in the hippocampus in patients with AD. This phenomenon has also been shown in patients with epilepsy and supports the hypothesis of hyperexcitability in patients with AD. The lack of a significant difference in hippocampal rCBF may be due to an increased frequency of epileptiform discharges in patients with AD. Trial registration The study is registered at clinicaltrials.gov (NCT04436341).

Funder

Copenhagen University

Publisher

Springer Science and Business Media LLC

Link

https://link.springer.com/content/pdf/10.1186/s13195-024-01432-9.pdf

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