Author:
Kmiołek Tomasz,Filipowicz Gabriela,Bogucka Diana,Wajda Anna,Ejma-Multański Adam,Stypińska Barbara,Modzelewska Ewa,Kaliberda Yana,Radkowski Marcin,Targowski Tomasz,Wrona Julia,Paradowska-Gorycka Agnieszka
Abstract
AbstractAging is a biological event that influences many organs and systems. Both sarcopenia and frailty syndrome refer to geriatric conditions with overlapping phenotypes. Many mechanisms are involved in the aging process such as DNA methylation telomeres which are susceptible to oxidative stress, and inflammations which result in telomere shortening, leading to chromosomal instability. The study aimed to determine the associations between these processes, frailty and sarcopenia syndrome. Global DNA methylation was analyzed using the ELISA method. Telomere length was analyzed using qPCR. Total oxidative status (TOS) was analyzed using a colorimetric method. The present study revealed that the main factor affecting methylation, telomeres length and level of total oxidant stress was age.
Publisher
Springer Science and Business Media LLC
Reference36 articles.
1. Kennedy BK, Berger SL, Brunet A, Campisi J, Cuervo AM, Epel ES, et al. Geroscience: linking aging to chronic disease. Cell. 2014;159:709–13.
2. Fulop T, Larbi A, Dupuis G, Le Page A, Frost EH, Cohen AA, et al. Ímmunosenescence and inflamm-aging as two sides of the same coin: friends or Foes?”. Front Immunol. 1960;2018:8.
3. De Martinis M, Franceschi C, Monti D, Ginaldi L. Inflamm-aging and lifelong antigenic load as major determinants of aging rate and longevity. FEBS Lett. 2005;579:2035–9.
4. Bucci L., Ostan R., Capri S., et al. ``Inflamm-aging: handbook on immunosenesce – basic understanding and clinical applications.” Springer Science+Business Media B.V. 2009; 839–918.
5. Goldman DP, Cutler D, Rowe JW, et al. Substantial health and economic returns from delayed aging may warrant a new focus for medical research. Health Aff. 2013;32(10):1698–705.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献