Author:
de Castro Mateus V.,Silva Monize V. R.,Naslavsky Michel S.,Scliar Marilia O.,Nunes Kelly,Passos-Bueno Maria Rita,Castelli Erick C.,Magawa Jhosiene Y.,Adami Flávia L.,Moretti Ana I. S.,de Oliveira Vivian L.,Boscardin Silvia B.,Cunha-Neto Edecio,Kalil Jorge,Jouanguy Emmanuelle,Bastard Paul,Casanova Jean-Laurent,Quiñones-Vega Mauricio,Sosa-Acosta Patricia,Guedes Jéssica de S.,de Almeida Natália P.,Nogueira Fábio C. S.,Domont Gilberto B.,Santos Keity S.,Zatz Mayana
Abstract
Abstract
Background
Although older adults are at a high risk of severe or critical Covid-19, there are many cases of unvaccinated centenarians who had a silent infection or recovered from mild or moderate Covid-19. We studied three Brazilian supercentenarians, older than 110 years, who survived Covid-19 in 2020 before being vaccinated.
Results
Despite their advanced age, humoral immune response analysis showed that these individuals displayed robust levels of IgG and neutralizing antibodies (NAbs) against SARS-CoV-2. Enrichment of plasma proteins and metabolites related to innate immune response and host defense was also observed. None presented autoantibodies (auto-Abs) to type I interferon (IFN). Furthermore, these supercentenarians do not carry rare variants in genes underlying the known inborn errors of immunity, including particular inborn errors of type I IFN.
Conclusion
These observations suggest that their Covid-19 resilience might be a combination of their genetic background and their innate and adaptive immunity.
Funder
Sao Paulo Research Foundation
United States National Institutes of Health
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior-Brasil
JBS S.A.
Publisher
Springer Science and Business Media LLC
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