The mechanism of ferroptosis and its related diseases

Author:

Feng Shijian,Tang Dan,Wang Yichang,Li Xiang,Bao Hui,Tang Chengbing,Dong Xiuju,Li Xinna,Yang Qinxue,Yan Yun,Yin Zhijie,Shang Tiantian,Zheng Kaixuan,Huang Xiaofang,Wei Zuheng,Wang Kunjie,Qi Shiqian

Abstract

AbstractFerroptosis, a regulated form of cellular death characterized by the iron-mediated accumulation of lipid peroxides, provides a novel avenue for delving into the intersection of cellular metabolism, oxidative stress, and disease pathology. We have witnessed a mounting fascination with ferroptosis, attributed to its pivotal roles across diverse physiological and pathological conditions including developmental processes, metabolic dynamics, oncogenic pathways, neurodegenerative cascades, and traumatic tissue injuries. By unraveling the intricate underpinnings of the molecular machinery, pivotal contributors, intricate signaling conduits, and regulatory networks governing ferroptosis, researchers aim to bridge the gap between the intricacies of this unique mode of cellular death and its multifaceted implications for health and disease. In light of the rapidly advancing landscape of ferroptosis research, we present a comprehensive review aiming at the extensive implications of ferroptosis in the origins and progress of human diseases. This review concludes with a careful analysis of potential treatment approaches carefully designed to either inhibit or promote ferroptosis. Additionally, we have succinctly summarized the potential therapeutic targets and compounds that hold promise in targeting ferroptosis within various diseases. This pivotal facet underscores the burgeoning possibilities for manipulating ferroptosis as a therapeutic strategy. In summary, this review enriched the insights of both investigators and practitioners, while fostering an elevated comprehension of ferroptosis and its latent translational utilities. By revealing the basic processes and investigating treatment possibilities, this review provides a crucial resource for scientists and medical practitioners, aiding in a deep understanding of ferroptosis and its effects in various disease situations.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Sichuan

1·3·5 Project for Disciplines of Excellence

Fundamental Research Funds for the Central Universities

Publisher

Springer Science and Business Media LLC

Subject

Molecular Medicine,Molecular Biology

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