A short review on lymphatic endothelial cell heterogeneity-Reference-Cited by-同舟云学术

A short review on lymphatic endothelial cell heterogeneity

Published:2021-10-11 Issue:1 Volume:41 Page:
ISSN:1880-8190
Container-title:Inflammation and Regeneration
language:en
Short-container-title:Inflamm Regener

Author:

Miyasaka Masayuki^ORCID

Abstract

AbstractRecent single-cell RNA sequencing studies in mouse and human have clearly indicated that lymphatic endothelial cells (LECs) consist of multiple cell subsets, each expressing a unique set of genes, residing in distinct locations in the body. These studies have also revealed a conserved pattern of gene expression in LECs across animal species, as well as specialized sets of genes unique to each species. However, the extent to which this heterogeneity is adaptive to the external milieu surrounding LECs has remained unclear. The transcriptional and regulatory pathways that program the different subsets of LECs also remain unexplored.

Publisher

Springer Science and Business Media LLC

Subject

Immunology,Immunology and Allergy

Link

https://link.springer.com/content/pdf/10.1186/s41232-021-00183-6.pdf

Reference11 articles.

1. Takeda A, Hollmén M, Dermadi D, Pan J, Brulois KF, Kaukonen R, et al. Single-cell survey of human lymphatics unveils marked endothelial cell heterogeneity and mechanisms of homing for neutrophils. Immunity. 2019;51(3):561–572.e5. https://doi.org/10.1016/j.immuni.2019.06.027.

2. Xiang M, Grosso RA, Takeda A, Pan J, Bekkhus T, Brulois K, et al. A single-cell transcriptional roadmap of the mouse and human lymph node lymphatic vasculature. Front Cardiovasc Med. 2020;7:52. https://doi.org/10.3389/fcvm.2020.00052.

3. Fujimoto N, He Y, D’Addio M, Tacconi C, Detmar M, Dieterich LC. Single-cell mapping reveals new markers and functions of lymphatic endothelial cells in lymph nodes. PLos Biol. 2020;18(4):e3000704. https://doi.org/10.1371/journal.pbio.3000704.

4. Sibler E, He Y, Ducoli L, Keller N, Fujimoto N, Dieterich LC, et al. Single-cell transcriptional heterogeneity of lymphatic endothelial cells in normal and inflamed murine lymph nodes. Cells. 2021;10(6):1371. https://doi.org/10.3390/cells10061371.

5. Pham TH, Baluk P, Xu Y, Grigorova I, Bankovich AJ, Pappu R, et al. Lymphatic endothelial sphingosine kinase activity is required for lymphocyte egress and lymphatic patterning. J Exp Med. 2010;207(1):17–27. https://doi.org/10.1084/jem.20091619.

Cited by 2 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Same yet different — how lymph node heterogeneity affects immune responses;Nature Reviews Immunology;2023-12-14

2. Editorial: Molecular Mechanisms and Signaling in Endothelial Cell Biology and Vascular Heterogeneity;Frontiers in Cell and Developmental Biology;2021-12-17