Transduction of the rat brain by Bovine Herpesvirus 4-Reference-Cited by-同舟云学术

Transduction of the rat brain by Bovine Herpesvirus 4

Published:2008-02-12 Issue:1 Volume:6 Page:
ISSN:1479-0556
Container-title:Genetic Vaccines and Therapy
language:en
Short-container-title:Genet Vaccines Ther

Author:

Redaelli Marco,Cavaggioni Andrea,Mucignat-Caretta Carla,Cavirani Sandro,Caretta Antonio,Donofrio Gaetano

Abstract

Abstract Bovine herpesvirus 4 (BoHV-4) is a gamma-herpesvirus with no clear disease association. A recombinant BoHV-4 (BoHV-4EGFPΔTK) expressing Green Fluorescent Protein (EGFP), was successfully used to infect F98 rat glioma cells. BoHV-4EGFPΔTK was injected into the lateral ventricle of the rat brain. Histology and immunohistochemistry showed that ependymal and rostral migratory stream cells were transduced while neurons were not. Clinical scores, evaluated for 90 days, indicated that the virus was non neuropathogenic, suggesting this virus is a suitable vector for brain tumor gene therapy.

Publisher

Springer Science and Business Media LLC

Subject

Molecular Medicine,Immunology,Immunology and Allergy,Biotechnology

Link

https://link.springer.com/content/pdf/10.1186/1479-0556-6-6.pdf

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