Author:
Utrera-Barillas Dolores,Valdez-Salazar Hilda-Alicia,Gómez-Rangel David,Alvarado-Cabrero Isabel,Aguilera Penélope,Gómez-Delgado Alejandro,Ruiz-Tachiquin Martha-Eugenia
Abstract
Abstract
Background
It has been hypothesized that human cytomegalovirus (HCMV) may be associated with breast cancer progression. However, the role of HCMV infection in breast cancer remains controversial. We aimed to assess whether HCMV genes (UL122 and UL83) could be detected in breast carcinomas and reinvestigated their possible association with breast cancer progression. DNA from paraffin-embedded tissues was analyzed by real-time PCR. We investigated 20 fibroadenomas and 27 primary breast carcinomas (stages II, III, and IV).
Findings
Two carcinomas were positive for HCMV, one was positive for two TaqMan viral detection probes, and one was positive for a sole TaqMan viral detection probe (UL83), whereas the remainder of the samples was negative.
Conclusions
Samples studied showed no association between HCMV infection and breast cancer progression.
Publisher
Springer Science and Business Media LLC
Subject
Cancer Research,Infectious Diseases,Oncology,Epidemiology
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