Abstract
Abstract
Background
Adolescence and early adulthood has been identified as a critical time window for establishing breast cancer risk. Mammographic density is an independent risk factor for breast cancer that may be influenced by diet, but there has been limited research conducted on the impact of diet on mammographic density. Thus, we sought to examine the association between adolescent and early adulthood inflammatory dietary patterns, which have previously been associated with breast cancer risk, and premenopausal mammographic density among women in the Nurses’ Health Study II (NHSII).
Methods
This study included control participants with premenopausal mammograms from an existing breast cancer case-control study nested within the NHSII who completed a Food Frequency Questionnaire in 1998 about their diet during high school (HS-FFQ) (n = 685) and/or a Food Frequency Questionnaire in 1991 (Adult-FFQ) when they were 27–44 years old (n = 1068). Digitized analog film mammograms were used to calculate the percent density, absolute dense, and non-dense areas. Generalized linear models were fit to evaluate the associations of a pro-inflammatory dietary pattern and the Alternative Healthy Eating Index (AHEI, an anti-inflammatory dietary pattern) with each breast density measure.
Results
Significant associations were observed between an adolescent pro-inflammatory dietary pattern and mammographic density in some age-adjusted models; however, these associations did not remain after adjustment for BMI and other breast cancer risk factors. No associations were observed with the pro-inflammatory pattern or with the AHEI pattern in adolescence or early adulthood in fully adjusted models.
Conclusions
To our knowledge, this is the first study to evaluate the dietary patterns during adolescence and early adulthood in relation to mammographic density phenotypes. Our findings do not support an association between adolescent and early adulthood diet and breast density in mid-adulthood that is independent of BMI or other breast cancer risk factors.
Funder
Breast Cancer Research Foundation
National Institutes of Health
National Institutes of Health, National Cancer Institute
Publisher
Springer Science and Business Media LLC
Reference46 articles.
1. World Cancer Research Fund AIfCR. Continuous update project report: Food, Nutrition, Physical Activity, and the Prevention of Breast Cancer; 2010.
2. Harris HR, Willett WC, Vaidya RL, Michels KB. Adolescent dietary patterns and premenopausal breast cancer incidence. Carcinogenesis. 2016;37(4):376–84. https://doi.org/10.1093/carcin/bgw023.
3. Colditz GA, Frazier AL. Models of breast-cancer show that risk is set by events of early-life - prevention efforts must shift focus. Cancer Epidem Biomar. 1995;4(5):567–71.
4. Harris HR, Willett WC, Vaidya RL, Michels KB. An adolescent and early adulthood dietary pattern associated with inflammation and the incidence of breast cancer. Cancer Res. 2017;77(5):1179–87. https://doi.org/10.1158/0008-5472.CAN-16-2273.
5. Hanna M, Dumas I, Orain M, Jacob S, Tetu B, Sanschagrin F, et al. Association between expression of inflammatory markers in normal breast tissue and mammographic density among premenopausal and postmenopausal women. Menopause. 2017;24(5):524–35. https://doi.org/10.1097/GME.0000000000000794.
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