Author:
Strand Siri H.,Houlahan Kathleen E.,Branch Vernal,Lynch Thomas,Rivero-Guitiérrez Belén,Harmon Bryan,Couch Fergus,Gallagher Kristalyn,Kilgore Mark,Wei Shi,DeMichele Angela,King Tari,McAuliffe Priscilla,Curtis Christina,Owzar Kouros,Marks Jeffrey R.,Colditz Graham A.,Hwang E. Shelley,West Robert B.
Abstract
Abstract
Background
Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer (IBC). Studies have indicated differences in DCIS outcome based on race or ethnicity, but molecular differences have not been investigated.
Methods
We examined the molecular profile of DCIS by self-reported race (SRR) and outcome groups in Black (n = 99) and White (n = 191) women in a large DCIS case-control cohort study with longitudinal follow up.
Results
Gene expression and pathway analyses suggested that different genes and pathways are involved in diagnosis and ipsilateral breast outcome (DCIS or IBC) after DCIS treatment in White versus Black women. We identified differences in ER and HER2 expression, tumor microenvironment composition, and copy number variations by SRR and outcome groups.
Conclusions
Our results suggest that different molecular mechanisms drive initiation and subsequent ipsilateral breast events in Black versus White women.
Funder
National Cancer Institute
Department of Defense
Breast Cancer Research Foundation
Publisher
Springer Science and Business Media LLC