Changes of synaptic vesicles in three-dimensional synapse models by treatment with umbelliferone in scopolamine-induced hippocampal injury model-Reference-Cited by-同舟云学术

Changes of synaptic vesicles in three-dimensional synapse models by treatment with umbelliferone in scopolamine-induced hippocampal injury model

Published:2024-01-23 Issue:1 Volume:54 Page:
ISSN:2287-4445
Container-title:Applied Microscopy
language:en
Short-container-title:Appl. Microsc.

Author:

Choi Ga-Young,Moon Eunyoung,Choi Hyosung,Kweon Hee-Seok^ORCID

Abstract

AbstractThe neuroprotective effects of umbelliferone (UMB) were visualized in three-dimensional (3D) images on vesicle density changes of organotypic hippocampal slice tissues (OHSCs) induced by scopolamine by high voltage electron microscopy. Observations revealed that the number of vesicles decreased in OHSCs induced by scopolamine, and UMB was found to inhibit scopolamine-induced reduction in vesicles, resulting in an increase in vesicle count. These 3D models provide valuable insight for understanding the increase of synapse vesicles in hippocampal tissues treated with UMB.

Funder

Ministry of Science and ICT, South Korea

Publisher

Springer Science and Business Media LLC

Subject

Applied Microbiology and Biotechnology,Microbiology

Link

https://link.springer.com/content/pdf/10.1186/s42649-024-00095-y.pdf

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