Occurrence of septuple and elevated Pfdhfr-Pfdhps quintuple mutations in a general population threatens the use of sulfadoxine-pyrimethamine for malaria prevention during pregnancy in eastern-coast of Tanzania

Author:

Bwire George M.,Mikomangwa Wigilya P.,Kilonzi Manase

Funder

Swedish International Development Cooperation Agency (Sida), Sweden

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases

Reference27 articles.

1. Patouillard E, Griffin J, Bhatt S, Ghani A, Cibulskis R. Global investment targets for malaria control and elimination between 2016 and 2030. BMJ Glob Health. 2017;2(2):e000176.

2. WHO. Global report on antimalarial drug efficacy and drug resistance: 2000–2010, vol. 115: Who; 2010.

3. Mohammed A, et al. Trends in chloroquine resistance marker , Pfcrt-K76T mutation ten years after chloroquine withdrawal in Tanzania. Malar J. 2013;12(1):1.

4. NDEJEMBI M, et al. Therapeutic efficacy of Sulfadoxine-Pyrimethamine and prevalence of resistance markers in Tanzania Prior to revision of malaria treatment policy: Plasmodium falciparum Dihydrofolate Reductase and Dihydropteroate synthase mutations in monitoring in vivo re. Am J Trop Med Hyg. 2018;71(6):696–702.

5. Mubyazi GM, Gonzalez-Block MA. Research influence on antimalarial drug policy change in Tanzania: case study of replacing chloroquine with sulfadoxine-pyrimethamine as the first-line drug. Malar J. 2005;4:1–13.

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