Author:
Guo Bianqin,Li Zheng,Fu Gang,Li Hong,Yang Jing,Zhang Zhenbin,Wu Lixiang,Wang Jing
Abstract
Abstract
Background
This work aimed to study natural humoral immune response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.
Methods
Chemiluminescent immunoassay (CLIA) was used to detect the neutralizing antibody (Nabs) and IgG.
Results
Nabs peaked on days 57–96 after symptom onset and remained detected on days 97–132. The Nabs in the 32 patients who were dynamically monitored showed four changing patterns. The titers of Nabs and IgG were correlated, and three modes of relationship were found between them.
Conclusions
Nabs showed a regular change in the course of coronavirus disease 2019 (COVID-19). The detection of Nabs is very important for monitoring the course of COVID-19 and predicting the strength of antibody protection.
Funder
the Coronavirus Disease 2019 Emergency Scientific Research Project of Chongqing University
Chongqing Natural Science Foundation Project
the medical scientific research project of Chongqing Health Commission
Publisher
Springer Science and Business Media LLC