Prognostic factors and outcomes of COVID-19 cases in Ethiopia: multi-center cohort study protocol

Author:

Abdella Saro,Tessema MasreshaORCID,Tasew Geremew,Defar Atkure,Deressa Asefa,Regasa Feyisa,Teka Frehiwot,Tigabu Eyasu,Nigussie Dereje,Belachew Tefera,Molla Million,Deribew Amare,Abebe Workeabeba,Yigzaw Tegbar,Nigatu Tsinuel,Mitike Getnet,Haile Tewodros,Taame Haftom,Ahmed Muhammed,Nigatu Frehiwot,Tolesa Tola,Wolka Eskinder,Amogne Wondwossen,Laillou Arnaud,Amare Misker,Fufa Yaregal,Argaw Alemayehu,Waganew Woldesenbet,Azazh Akilili,Worku Aschalew,Redae Berhane,Sultan Menbeu,Walelegn Miraf,Tefera Muluwork,Yifru Sisay,Argaw Rahel,Brehau Natinael,Teklu Sisay,Demoz Getachew,Seman Yakob,Salasibew Mihretab,Ejeta Eshetu,Whiting Susan J.,Wolday Dawit,Tollera Getachew,Abate Ebba,Duguma Dereje

Abstract

Abstract Background The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) and became pandemic after emerging in Wuhan, China, in December 2019. Several studies have been conducted to understand the key features of COVID-19 and its public health impact. However, the prognostic factors of COVID-19 are not well studied in the African setting. In this study, we aim to determine the epidemiological and clinical features of COVID-19 cases, immunological and virological courses, interaction with nutritional status, and response to treatment for COVID-19 patients in Ethiopia. Methods A multi-center cohort study design will be performed. Patients with confirmed COVID-19 infection admitted to selected treatment centers will be enrolled irrespective of their symptoms and followed-up for 12 months. Baseline epidemiological, clinical, laboratory and imaging data will be collected from treatment records, interviews, physical measurements, and biological samples. Follow-up data collection involves treatment and prognostic outcomes to be measured using different biomarkers and clinical parameters. Data collection will be done electronically using the Open Data Kit (ODK) software package and then exported to STATA/SPSS for analysis. Both descriptive and multivariable analyses will be performed to assess the independent determinants of the treatment outcome and prognosis to generate relevant information for informed prevention and case management. The primary outcomes of this study are death/survival and viral shedding. Secondary outcomes include epidemiological characteristics, clinical features, genetic frequency shifts (genotypic variations), and nutritional status. Discussion This is the first large prospective cohort study of patients in hospitals with COVID-19 in Ethiopia. The results will enable us to better understand the epidemiology of SARS-CoV-2 in Africa. This study will also provide useful information for effective public health measures and future pandemic preparedness and in response to outbreaks. It will also support policymakers in managing the epidemic based on scientific evidence. Trial Registration: The Protocol prospectively registered in ClinicalTrials.gov (NCT04584424) on 30 October, 2020.

Funder

Ministry of Health, Ethiopia

International Institute for Primary Heath Care-Ethiopia

Publisher

Springer Science and Business Media LLC

Subject

Infectious Diseases

Reference30 articles.

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