Author:
Leite Pedro H. A. C.,Coelho Lara E.,Cardoso Sandra W.,Moreira Ronaldo I.,Veloso Valdilea G.,Grinsztejn Beatriz,Luz Paula M.
Abstract
Abstract
Background
Global mortality from AIDS-related diseases has been declining since 2005, resulting primarily from the widespread use and early initiation of combination antiretroviral therapy. Despite the significant improvements, high rates of early mortality, usually defined as that occurring within the 1st year of entry to care, have been observed, especially in resource-limited settings. This analysis draws upon data from an observational cohort of people with HIV (PWH) followed at a reference center for HIV/AIDS care and research in the city of Rio de Janeiro, Brazil, to identify the pattern and factors associated with early mortality.
Methods
The study population includes PWH aged 18 or older followed at the National Institute of Infectious Diseases Evandro Chagas who were enrolled between 2004 and 2015. The primary outcome was early mortality, defined as deaths occurring within 1 year of inclusion in the cohort, considering two follow-up periods: 0 to 90 days (very early mortality) and 91 to 365 days (early mortality). Cox proportional hazards models were used to identify the variables associated with the hazard of very early and early mortality.
Results
Overall, 3879 participants contributed with 3616.4 person-years of follow-up. Of 220 deaths, 132 happened in the first 90 days and 88 between 91 and 365 days. Very early mortality rate ratios (MRR) show no statistically significant temporal differences between the periods 2004–2006 to 2013–2015. In contrast, for early mortality, a statistically significant decreasing trend was observed: mortality rates in the periods 2004–2006 (MR = 5.5; 95% CI 3.9–7.8) and 2007–2009 (MR = 3.9; 95% CI 2.7–5.7) were approximately four and three-fold higher when compared to 2013–2015 (MR = 1.4; 95% CI 0.7–2.7). Low CD4 count and prior AIDS-defining illness were strongly associated with higher hazard ratios of death, especially when considering very early mortality.
Conclusions
The present study shows an excess of mortality in the 1st year of follow-up with no changes in the mortality rates within 90 days among PWH from Rio de Janeiro. We note the significant impact of initiating treatment with immunosuppression, as evidenced by the increased risk of death among those with low CD4 cell count and with AIDS-defining illnesses.
Funder
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro
NIH-funded Caribbean, Central and South America network for HIV epidemiology (CCASAnet), a member cohort of the International Epidemiologic Databases to Evaluate AIDS
Publisher
Springer Science and Business Media LLC
Reference70 articles.
1. Centers for Disease Control and Prevention. 1993 Revised Classification System for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. 1992. https://www.cdc.gov/mmwr/preview/mmwrhtml/00018871.htm. Accessed 9 Feb 2020.
2. Brasil. Recomendações para Terapia Anti-Retroviral em Adultos e Adolescentes Infectados pelo HIV 2004. Brasília: Ministério da Saúde. Secretaria de Vigilância em Saúde. Programa Nacional de DST e Aids; 2004.
3. Programa Nacional de DST e Aids. Recomendações para terapia anti-retroviral em adultos infectados pelo HIV: 2008. Brasília: Programa Nacional de DST e Aids; 2008.
4. Brasil. Protocolo Clínico e Diretrizes Clínicas para Manejo da Infecção pelo HIV em Adultos. Brasília, DF: Ministério da Saúde. Secretaria de Vigilância em Saúde. Departamento de Vigilância, Prevenção e Controle das Infecções Sexualmente Transmissíveis, do HIV/Aids e das Hepatites Virais; 2018.
5. Grinsztejn B, Luz PM, Pacheco AG, Santos DVG, Velasque L, Moreira RI, et al. Changing mortality profile among HIV-infected patients in Rio de Janeiro, Brazil: shifting from AIDS to non-AIDS related conditions in the HAART Era. PLoS ONE. 2013;8:e59768.
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