Abstract
Abstract
Background
Blood transfusion is one of the routine therapeutic interventions in hospitals that can be lifesaving. However, this intervention is related to several transfusion-related infections. Hepatitis C viral infection is one of the most common causes of transfusion-related hepatitis. Subsequently, this systematic review and meta-analysis was aimed to estimate the seroprevalence of hepatitis C virus infection among blood donors in Ethiopia.
Methods
PubMed, Google Scholar, Health InterNetwork Access to Research Initiative (HINARI), Excerpta Medica database (EMBASE), and Cochrane library, the web of science, African journal of online (AJOL), and Google Scholar was searched. The data were extracted using Microsoft Excel and analyzed by using STATA version 14. Publication bias was checked by funnel plot, contour-enhanced funnel plots, trim and fill analysis and more objectively through Egger’s regression test, with P < 0.05 considered to indicate potential publication bias. The heterogeneity of studies was checked using I2 statistics. Pooled analysis was conducted using a weighted inverse variance random-effects model. Subgroup analysis was done by region and study period. A sensitivity analysis was employed.
Result
A total of 25 studies with 197,172 study participants were used to estimate the seroprevalence of hepatitis c virus among blood donors. The overall seroprevalence of hepatitis C virus was 0.819% (95% CI: 0.67–0.969; I2 = 92.3%). Regional sub-group analysis showed that the pooled prevalence of hepatitis c virus infection among blood donors found to be 0.563% in Somali, 1.08% in Oromia, 0.847% in Amhara, and 0.908% in south nations nationalities and peoples region.
Conclusion
The pooled seroprevalence of hepatitis C virus infection among blood donors in Ethiopia found to be low. Moreover, there should be systematic strategies that enhance donor screening and retention of safe regular donors.
Publisher
Springer Science and Business Media LLC
Reference55 articles.
1. Arshad A, Borhany M, Anwar N, Naseer I, Ansari R, Boota S, Fatima N, Zaidi M, Shamsi T. Prevalence of transfusion transmissible infections in blood donors of Pakistan. BMC Hematol. 2016;16(1):27.
2. World Health Organization. Screening donated blood for transfusion-transmissible infections: recommendations. World Health Organization; 2010. Available at https://www.who.int/bloodsafety/publications/9789241547888/en/.
3. Ethiopian Red Cross Society. Historical Background; 2010. p. 1–2.
4. Walana W, Ahiaba S, Hokey P, Vicar EK, Acuqah SE, Der EM, Ziem TB. Sero-prevalence of HIV, HBV and HCV among blood donors in the Kintampo Municipal Hospital, Ghana. Br Microbiol Res J. 2014;4(12):1491–9. https://doi.org/10.9734/BMRJ/2014/12160.
5. Choo QL, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M. Isolation of a cDNA clone derived from a blood-borne non-a, non-B viral hepatitis genome. Science. 1989;244(4902):359–62.