Author:
Wagnew Fasil,Eshetie Setegn,Alebel Animut,Tesema Cheru,Kibret Getiye Dejenu,Gebrie Alemu,Dessie Getenet,Abajobir Amanuel Alemu
Abstract
Abstract
Background
Anemia is a common problem in HIV (human immunodeficiency virus) infected patients, and is associated with decreased functional capacity and quality of life. Ethiopia is one of the countries which has expanded highly active antiretroviral treatment (HAART) over the past years. The effect of HAART on anemia among HIV remains inconsistent and inconclusive, particularly in children. This study thus aimed to synthesize the prevalence of anemia among HIV infected Ethiopian children and its association with HAART initiation.
Methods
MEDLINE/PubMed, EMBASE, PsycINFO, Web of Science and Google scholar were used to identify 12 eligible studies reporting an association between anemia and HIV using a priori set criteria. PRISMA guideline was used to systematically review and meta-analysis these studies. Details of sample size, magnitude of effect sizes, including odds ratio (OR) and standard errors were extracted. Random-effects model was used to calculate the pooled estimates using STATA/SE version-14. I2 and meta-bias statistics assessed heterogeneity and publication bias of the included studies. Sub-group analyses, based on study designs, were also carried out.
Results
In Ethiopia, the overall prevalence of anemia in HIV infected children was 22.3% (95% CI: 18.5–26.0%). The OR of anemia-HIV/AIDS comorbidity was 0.4 (95% CI, 0.2–0.5) in HAART initiated children as compared to non-initiated counterparts. Meta-bias and funnel plot detected no publication bias.
Conclusion
On aggregate, anemia is a common comorbidity in pediatric HIV patients. HAART was significantly associated with a reduced anemia-HIV/AIDS comorbidity. Prompt start of HAART might help decreasing the prevalence of anemia and its subsequent complications.
Publisher
Springer Science and Business Media LLC
Reference64 articles.
1. Demographic E. Health survey 2011 central statistical agency Addis Ababa. Maryland: Ethiopia ICF International Calverton; 2012.
2. Balarajan Y, Ramakrishnan U, Özaltin E, Shankar AH, Subramanian S. Anaemia in low-income and middle-income countries. Lancet. 2011;378(9809):2123–35.
3. WHO. Focusing on anaemia: towards an integrated approach for effective anaemia control. Geneva: WHO; 2004.
4. Health FDRoEMo: National comprehensive and integrated prevention of mother-to-child transmission of hiv guideline, Addis Ababa, Ethiopia 2017.
5. Mullu G. Mother-to-child transmission of HIV infection and its associated factors in Ethiopia: a systematic review and meta-analysis. BMC Infect Dis. 2018;18(1):216.
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