Author:
Ramillon Julien,de Lamballerie Xavier,Robineau Olivier,Blanché Hélène,Severi Gianluca,Touvier Mathilde,Zins Marie,Carrat Fabrice,Ancel Pierre-Yves,Charles Marie-Aline,Kab Sofiane,Renuy Adeline,Le-Got Stéphane,Ribet Céline,Wiernik Emmanuel,Goldberg Marcel,Artaud Fanny,Gerbouin-Rérolle Pascale,Enguix Melody,Laplanche Camille,Gomes-Rima Roselyn,Hoang Lyan,Correia Emmanuelle,Barry Alpha Amadou,Senina Nadège,Szabo de Edelenyi Fabien,Druesne-Pecollo Nathalie,Esseddik Younes,Hercberg Serge,Benhammou Valérie,Ritmi Anass,Marchand Laetitia,Zaros Cécile,Lordmi Elodie,Candea Adriana,de Visme Sophie,Simeon Thierry,Thierry Xavier,Geay Bertrand,Dufourg Marie-Noëlle,Milcent Karen,Lusivika-Nzinga Clovis,Pannetier Gregory,Lapidus Nathanael,Goderel Isabelle,Dorival Céline,Nicol Jérôme,Lai Cindy,Esperou Hélène,Couffin-Cadiergues Sandrine,Gagliolo Jean-Marie,Sebaoun Jean-Marc,Beaudoin Jean-Christophe,Gressin Laetitia,Morel Valérie,Ouili Ouissam,Deleuze Jean-Francois,Priet Stephane,Saba Villarroel Paola Mariela,Fourié Toscane,Mohamed Ali Souand,Amroun Abdenour,Seston Morgan,Ayhan Nazli,Pastorino Boris,Pellicer Mireille,Allegre Julien,Deschasaux Mélanie,Rahib Delphine,Lydie Nathalie,Robineau Olivier,Belhadji Liza,Ninove Laetitia,Bajos Nathalie,Ancel Pierre-Yves,Charles Marie-Aline,Jusot Florence,Martin Claude,Meyer Laurence,Pailhe Ariane,Spire Alexis,Rouquette Alexandra,Lapidus Nathanaël, ,
Abstract
Abstract
Background
Taste or smell disorders have been reported as strongly associated with COVID-19 diagnosis. We aimed to identify subject characteristics, symptom associations, and antibody response intensity associated with taste or smell disorders.
Methods
We used data from SAPRIS, a study based on a consortium of five prospective cohorts gathering 279,478 participants in the French general population. In the analysis, we selected participants who were presumably infected by SARS-CoV-2 during the first epidemic wave.
Results
The analysis included 3,439 patients with a positive ELISA-Spike. Sex (OR = 1.28 [95% CI 1.05–1.58] for women), smoking (OR = 1.54 [95% CI 1.13–2.07]), consumption of more than 2 drinks of alcohol a day (OR = 1.37 [95% CI 1.06–1.76]) were associated with a higher probability of taste or smell disorders. The relationship between age and taste or smell disorders was non-linear. Serological titers were associated with taste or smell disorders: OR = 1.31 [95% CI 1.26–1.36], OR = 1.37 [95% CI 1.33–1.42] and OR = 1.34 [95% CI 1.29–1.39] for ELISA-Spike, ELISA-Nucleocapsid and seroneutralization, respectively. Among participants with taste or smell disorders, 90% reported a wide variety of other symptoms whereas 10% reported no other symptom or only rhinorrhea.
Conclusions
Among patients with a positive ELISA-Spike test, women, smokers and people drinking more than 2 drinks a day were more likely to develop taste or smell disorders. This symptom was strongly associated with an antibody response. The overwhelming majority of patients with taste or smell disorders experienced a wide variety of symptoms.
Publisher
Springer Science and Business Media LLC