Author:
Tsurkalenko Olena,Bulaev Dmitry,O’Sullivan Marc Paul,Snoeck Chantal,Ghosh Soumyabrata,Kolodkin Alexey,Rommes Basile,Gawron Piotr,Moreno Carlos Vega,Gomes Clarissa P. C.,Kaysen Anne,Ohnmacht Jochen,Schröder Valerie E.,Pavelka Lukas,Meyers Guilherme Ramos,Pauly Laure,Pauly Claire,Hanff Anne-Marie,Meyrath Max,Leist Anja,Sandt Estelle,Aguayo Gloria A.,Perquin Magali,Gantenbein Manon,Abdelrahman Tamir,Klucken Jochen,Satagopam Venkata,Hilger Christiane,Turner Jonathan,Vaillant Michel,Fritz Joëlle V.,Ollert Markus,Krüger Rejko, ,Acharya Geeta,Alper Pinar,Ammerlaan Wim,Ancien François,Assele-Kama Ariane,Bahlawane Christelle,Beaumont Katy,Beaupain Nadia,Beckers Lucrèce,Bellora Camille,Betsou Fay,Biver Luc,Boly Sandie,Brenner Dirk,Cauchie Henry-Michel,Charalambous Eleftheria,Charpentier Emilie,Coibion Estelle,Coito Sylvie,Collart Delphine,Counson Manuel,De Witt Brian,Di Pasquale Antonelle,Domingues Olivia,Dording Claire,Dourson Jean-Luc,Dragomir Bianca,Fautsch Tessy,Ferrand Jean-Yves,Ferrandon Thibault,Lopes Ana Festas,Fournier Guillaume,Georges Laura,Gidenne Stéphane,Glaab Enrico,Ramos Borja Gomez,Gorgogietas Vyron,Graas Jérôme,Groues Valentin,Gu Wei,Hamot Gael,Hansen Maxime,Hansen Linda,Hefele Lisa,Heirendt Laurent,Hemedan Ahmed,Henry Estelle,Henry Margaux,Herkenne Eve,Herzinger Sascha,Huiart Laetitia,Hundt Alexander,Hübschen Judith,Iserentant Gilles,Jägi Philipp,Khurmin Piyapong,Klein Fédéric,Klein Tommy,Kler Stéphanie,Lambert Pauline,Lebioda Jacek Jaroslaw,Lehmann Sabine,Leick Marie,Lemaire Morgane,Lumley Andrew,Lutz Annika,Loureiro João Manuel,Marchese Monica,Marques Tainà,Massart François,May Patrick,Minelli Maura,Mousel Alessandra,Munsch Maeva,Mériaux Sophie,Mühlschlegel Friedrich,Neumann Mareike,Nguyen Trang,Nicolai Beatrice,Ogorzaly Leslie,Olesky Christiane,Penny Christian,Pexaras Achilleas,di Pinto Palma,Pirard Marie France,Plesseria Jean-Marc,Rauschenberger Armin,Remark Lucie,Rodriguez Antonio,Rump Kirsten,Santos Bruno,Sausy Aurélie,Schmitt Margaux,Schmitt Christiane,Schneider Reinhard,Schumacher Serge,Schweicher Alexandra,Seal Sneeha,Servais Jean-Yves,Simon Florian,Skrozic Amna,Sokolowska Kate,Stute Lara,Thien Hermann,Toll Stéphane,Toukourou Noua,Trefois Christophe,Trouet Johanna,Trung Nguyen,Esteves Daniela Valoura,Verschueren Charlène,Vyas Maharshi,Vögele Claus,Walczak Cécile,Wang Xinhui,Wauters Femke,Weber Bernard,Weibel Emilie,Zamboni Tania
Abstract
Abstract
Background
During the COVID-19 pandemic swift implementation of research cohorts was key. While many studies focused exclusively on infected individuals, population based cohorts are essential for the follow-up of SARS-CoV-2 impact on public health. Here we present the CON-VINCE cohort, estimate the point and period prevalence of the SARS-CoV-2 infection, reflect on the spread within the Luxembourgish population, examine immune responses to SARS-CoV-2 infection and vaccination, and ascertain the impact of the pandemic on population psychological wellbeing at a nationwide level.
Methods
A representative sample of the adult Luxembourgish population was enrolled. The cohort was followed-up for twelve months. SARS-CoV-2 RT-qPCR and serology were conducted at each sampling visit. The surveys included detailed epidemiological, clinical, socio-economic, and psychological data.
Results
One thousand eight hundred sixty-five individuals were followed over seven visits (April 2020—June 2021) with the final weighted period prevalence of SARS-CoV-2 infection of 15%. The participants had similar risks of being infected regardless of their gender, age, employment status and education level. Vaccination increased the chances of IgG-S positivity in infected individuals. Depression, anxiety, loneliness and stress levels increased at a point of study when there were strict containment measures, returning to baseline afterwards.
Conclusion
The data collected in CON-VINCE study allowed obtaining insights into the infection spread in Luxembourg, immunity build-up and the impact of the pandemic on psychological wellbeing of the population. Moreover, the study holds great translational potential, as samples stored at the biobank, together with self-reported questionnaire information, can be exploited in further research.
Trial registration
Trial registration number: NCT04379297, 10 April 2020.