Author:
Yuan Chien-Han,Hsu Wei-Chi,Huang A.-Mei,Yuan Ben-Chih,Chen I.-Hung,Hsu Chia-An,Chen Rong-Feng,Chu Yih-Min,Lin Hui-Hui,Ke Hung-Lung
Abstract
Abstract
Background
In several human cancers, Krüppel-like factor 5 (KLF5), a zinc finger transcription factor, can contribute to both tumor progression or suppression; however, the precise role of KLF5 in nasopharyngeal carcinoma (NPC) remains poorly understood. In this study, the association between KLF5 and microRNA-145-5p (miR-145-5p) in NPC cells was elucidated.
Results
Our results showed that KLF5 expression was up-regulated in NPC group compared to normal group. We found that KLF5 exhibited an oncogenic role in NPC cells. The upregulation of miR-145-5p inhibited the proliferation, migration, and invasion of NPC cells. It was observed that miR-145-5p could down-regulate the mRNA and protein expression of KLF5 in NPC cell lines. Additionally, the activity of focal adhesion kinase (FAK), a migration marker, was regulated by miR-145-5p and KLF5 in NPC cells.
Conclusions
The results of this study indicated that miR-145-5p could repress the proliferation, migration, and invasion of NPC cells via KLF5/FAK regulation, and could be a potential therapeutic target for patients with NPC.
Funder
Kaohsiung Armed Forces General Hospital
Publisher
Springer Science and Business Media LLC
Subject
Cell Biology,Molecular Biology
Cited by
2 articles.
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