Author:
Fang Jie,Wu Jielong,Zhang Tengkun,Yuan Xiaodong,Zhao Jiedong,Zheng Liangcheng,Hong Ganji,Yu Lu,Lin Qing,An Xingkai,Jing Chuya,Zhang Qiuhong,Wang Chen,Wang Zhanxiang,Ma Qilin
Abstract
Abstract
Purpose
Serum neurofilament light chain (sNfL) can reflect nerve damage. Whether migraine can cause neurological damage remain unclear. This study assesses sNfL levels in migraine patients and explores whether there is nerve damage in migraine.
Methods
A case–control study was conducted in Xiamen, China. A total of 138 migraine patients and 70 healthy controls were recruited. sNfL (pg/mL) was measured on the single-molecule array platform. Univariate, Pearson correlation and linear regression analysis were used to assess the relationship between migraine and sNfL levels, with further subgroup analysis by migraine characteristics.
Results
Overall, 85.10% of the 208 subjects were female, with a median age of 36 years. sNfL levels were higher in the migraine group than in the control group (4.85 (3.49, 6.62) vs. 4.11 (3.22, 5.59)), but the difference was not significant (P = 0.133). The two groups showed an almost consistent trend in which sNfL levels increased significantly with age. Subgroup analysis showed a significant increase in sNfL levels in patients with a migraine course ≥ 10 years (β = 0.693 (0.168, 1.220), P = 0.010). Regression analysis results show that age and migraine course are independent risk factors for elevated sNfL levels, and there is an interaction between the two factors. Patients aged < 45 years and with a migraine course ≥ 10 years have significantly increased sNfL levels.
Conclusions
This is the first study to evaluate sNfL levels in migraine patients. The sNfL levels significantly increased in patients with a migraine course ≥ 10 years. More attention to nerve damage in young patients with a long course of migraine is required.
Funder
Natural Science Foundation of Fujian Province
Medical and Health Key Project of Xiamen
Natural Science Foundation of China
Xiamen Municipal Health Commission, Xiamen Municipal Bureau of Science and Technology
Key Project of Natural Science Foundation of Fujian Province
Publisher
Springer Science and Business Media LLC
Subject
Anesthesiology and Pain Medicine,Neurology (clinical),General Medicine