Author:
Labastida-Ramírez Alejandro,Caronna Edoardo,Gollion Cédric,Stanyer Emily,Dapkute Austeja,Braniste Diana,Naghshineh Hoda,Meksa Liga,Chkhitunidze Nino,Gudadze Tamari,Pozo-Rosich Patricia,Burstein Rami,Hoffmann Jan
Abstract
AbstractTargeting CGRP has proved to be efficacious, tolerable, and safe to treat migraine; however, many patients with migraine do not benefit from drugs that antagonize the CGRPergic system. Therefore, this review focuses on summarizing the general pharmacology of the different types of treatments currently available, which target directly or indirectly the CGRP receptor or its ligand. Moreover, the latest evidence regarding the selectivity and site of action of CGRP small molecule antagonists (gepants) and monoclonal antibodies is critically discussed. Finally, the reasons behind non-responders to anti-CGRP drugs and rationale for combining and/or switching between these therapies are addressed.
Publisher
Springer Science and Business Media LLC
Subject
Anesthesiology and Pain Medicine,Neurology (clinical),General Medicine
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