Author:
He Qiang,Wang Wenjing,Xiong Yang,Tao Chuanyuan,Ma Lu,Ma Junpeng,You Chao,Anttila Verneri,Artto Ville,Belin Andrea C.,Bjornsdottir Anna,Bjornsdottir Gyda,Boomsma Dorret I.,Børte Sigrid,Chalmer Mona A.,Chasman Daniel I.,Cormand Bru,Cuenca-Leon Ester,Davey-Smith George,de Boer Irene,Dichgans Martin,Esko Tonu,Freilinger Tobias,Gormley Padhraig,Griffiths Lyn R.,Hämäläinen Eija,Hansen Thomas F.,Harder Aster V. E.,Hautakangas Heidi,Hiekkala Marjo,Hrafnsdottir Maria G.,Ikram M. Arfan,Järvelin Marjo-Riitta,Kajanne Risto,Kallela Mikko,Kaprio Jaakko,Kaunisto Mari,Kogelman Lisette J. A.,Kristoffersen Espen S.,Kubisch Christian,Kurki Mitja,Kurth Tobias,Launer Lenore,Lehtimäki Terho,Lessel Davor,Ligthart Lannie,Magnusson Sigurdur H.,Malik Rainer,Müller-Myhsok Bertram,Northover Carrie,Nyholt Dale R.,Olesen Jes,Palotie Aarno,Palta Priit,Pedersen Linda M.,Pedersen Nancy,Pirinen Matti,Posthuma Danielle,Pozo-Rosich Patricia,Pressman Alice,Raitakari Olli,Ran Caroline,Sigurdardottir Gudrun R.,Stefansson Hreinn,Stefansson Kari,Sveinsson Olafur A.,Terwindt Gisela M.,Thorgeirsson Thorgeir E.,van den Maagdenberg Arn M. J. M.,van Duijn Cornelia,Wessman Maija,Winsvold Bendik S.,Zwart John-Anker,
Abstract
Abstract
Background
The causal association between the gut microbiome and the development of migraine and its subtypes remains unclear.
Methods
The single nucleotide polymorphisms concerning gut microbiome were retrieved from the gene-wide association study (GWAS) of the MiBioGen consortium. The summary statistics datasets of migraine, migraine with aura (MA), and migraine without aura (MO) were obtained from the GWAS meta-analysis of the International Headache Genetics Consortium (IHGC) and FinnGen consortium. Inverse variance weighting (IVW) was used as the primary method, complemented by sensitivity analyses for pleiotropy and increasing robustness.
Results
In IHGC datasets, ten, five, and nine bacterial taxa were found to have a causal association with migraine, MA, and MO, respectively, (IVW, all P < 0.05). Genus.Coprococcus3 and genus.Anaerotruncus were validated in FinnGen datasets. Nine, twelve, and seven bacterial entities were identified for migraine, MA, and MO, respectively. The causal association still exists in family.Bifidobacteriaceae and order.Bifidobacteriales for migraine and MO after FDR correction. The heterogeneity and pleiotropy analyses confirmed the robustness of IVW results.
Conclusion
Our study demonstrates that gut microbiomes may exert causal effects on migraine, MA, and MO. We provide novel evidence for the dysfunction of the gut-brain axis on migraine. Future study is required to verify the relationship between gut microbiome and the risk of migraine and its subtypes and illustrate the underlying mechanism between them.
Publisher
Springer Science and Business Media LLC
Subject
Anesthesiology and Pain Medicine,Neurology (clinical),General Medicine