Abstract
Abstract
Background
Papaya (Carica papaya Linn.) is well known for its nutritional as well as medicinal value. Different parts of the plant including leaves have been used as therapeutic remedies for various diseases. The objective of the present study is to determine the impact of different extraction methods; microwave-assisted, ultrasonic-assisted and conventional maceration on extract yield, polyphenols, flavonoids composition and subsequently, the anti-hyperlipidemic potential of papaya leaves (Carica papaya Linn.).
Results
Innovative extraction methods represented in microwave assisted extraction (MAE) and ultrasonic assisted extraction (UAE) have significant impact on the extract yield and total phenolic and flavonoids content than conventional maceration extraction (CME) of the prepared aqueous ethanol extracts. HPLC assay showed the highest content of bioactive polyphenols characterized extract from the MAE (29.99 mg/g), followed by UAE (24.75 mg/g) and the lowest content was that obtained from CME. The aqueous ethanol extract of the leaves obtained by MAE induced significant hypolipidemic activity (P < 0.05) in hyperlipidemic rats particularly, the oral treatment with 200 mg/kg b.wt. which retained the lipid profile to be compatible to the results of rats receiving simvastatin (0.18 mg/kg b.w.).
Conclusion
The results substantiate traditional usage and recommend the potential utilization of Carica papaya leaves for its’ beneficial therapeutic effects.
Publisher
Springer Science and Business Media LLC
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