AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity-Reference-Cited by-同舟云学术

AM404, paracetamol metabolite, prevents prostaglandin synthesis in activated microglia by inhibiting COX activity

Published:2017-12 Issue:1 Volume:14 Page:
ISSN:1742-2094
Container-title:Journal of Neuroinflammation
language:en
Short-container-title:J Neuroinflammation

Author:

Saliba Soraya Wilke,Marcotegui Ariel R.,Fortwängler Ellen,Ditrich Johannes,Perazzo Juan Carlos,Muñoz Eduardo,de Oliveira Antônio Carlos Pinheiro,Fiebich Bernd L.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Deutscher Akademischer Austauschdienst

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology,Immunology,General Neuroscience

Link

http://link.springer.com/content/pdf/10.1186/s12974-017-1014-3.pdf

Reference62 articles.

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3. Högestätt ED, Jönsson BAG, Ermund A, Andersson DA, Björk H, Alexander JP, et al. Conversion of acetaminophen to the bioactive N-acylphenolamine AM404 via fatty acid amide hydrolase-dependent arachidonic acid conjugation in the nervous system. J Biol Chem. 2005;280:31405–12.

4. Bertolini A, Ferrari A, Ottani A, Guerzoni S, Tacchi R, Leone S. Paracetamol: new vistas of an old drug. CNS Drug Rev. 2006;12:250–75.

5. Bisogno T, De Petrocellis L, Di Marzo V. Fatty acid amide hydrolase, an enzyme with many bioactive substrates. Possible therapeutic implications. Curr Pharm Des. 2002;8:533–47.

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