Author:
Zhu Sibo,Jiang Yanfeng,Xu Kelin,Cui Mei,Ye Weimin,Zhao Genming,Jin Li,Chen Xingdong
Abstract
AbstractThere is increasing evidence showing that the dynamic changes in the gut microbiota can alter brain physiology and behavior. Cognition was originally thought to be regulated only by the central nervous system. However, it is now becoming clear that many non-nervous system factors, including the gut-resident bacteria of the gastrointestinal tract, regulate and influence cognitive dysfunction as well as the process of neurodegeneration and cerebrovascular diseases. Extrinsic and intrinsic factors including dietary habits can regulate the composition of the microbiota. Microbes release metabolites and microbiota-derived molecules to further trigger host-derived cytokines and inflammation in the central nervous system, which contribute greatly to the pathogenesis of host brain disorders such as pain, depression, anxiety, autism, Alzheimer’s diseases, Parkinson’s disease, and stroke. Change of blood–brain barrier permeability, brain vascular physiology, and brain structure are among the most critical causes of the development of downstream neurological dysfunction. In this review, we will discuss the following parts:
Overview of technical approaches used in gut microbiome studiesMicrobiota and immunityGut microbiota and metabolitesMicrobiota-induced blood–brain barrier dysfunctionNeuropsychiatric diseases
■ Stress and depression■ Pain and migraine■ Autism spectrum disordersNeurodegenerative diseases
■ Parkinson’s disease■ Alzheimer’s disease■ Amyotrophic lateral sclerosis■ Multiple sclerosisCerebrovascular disease
■ Atherosclerosis■ Stroke■ Arteriovenous malformationConclusions and perspectives
Funder
National Key Research and Development program of China
National Natural Science Foundation of China
International Science and Technology Cooperation Programme
the Key Basic Research Grants from Science and Technology Commission of Shanghai Municipality, China
Science and Technology Commission of Shanghai Municipality
Publisher
Springer Science and Business Media LLC
Subject
Cellular and Molecular Neuroscience,Neurology,Immunology,General Neuroscience
Cited by
236 articles.
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