Human microglia and astrocytes constitutively express the neurokinin-1 receptor and functionally respond to substance P

Author:

Burmeister Amanda R.,Johnson M. Brittany,Chauhan Vinita S.,Moerdyk-Schauwecker Megan J.,Young Ada D.,Cooley Ian D.,Martinez Alejandra N.,Ramesh Geeta,Philipp Mario T.,Marriott Ian

Funder

National Institute of Neurological Disorders and Stroke

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology,Immunology,General Neuroscience

Reference34 articles.

1. Martinez AN, Philipp MT. Substance P and antagonists of the neurokinin-1 receptor in neuroinflammation associated with infectious and neurodegenerative diseases of the central nervous system. J Neurol Neuromedicine. 2016;1:29–36.

2. Johnson MB, Young A, Marriott I. The therapeutic potential of targeting substance P/NK-1R interactions in inflammatory CNS disorders. Front Cell Neurosci. 2016; In Press

3. Bost KL. Tachykinin-modulated anti-viral responses. Front Biosci. 2004;9:1994–8.4.

4. Robinson P, Garza A, Moore J, Eckols TK, Parti S, Balaji V, Vallejo J, Tweardy DJ. SP is required for the pathogenesis of EMCV infection in mice. Int J Clin Exp Med. 2009;2:76–86.

5. Kennedy PG, Rodgers J, Jennings FW, Murray M, Leeman SE, Burke JM. A SP antagonist, RP-67,580, ameliorates a mouse meningoencephalitic response to Trypanosoma brucei brucei. Proc Natl Acad Sci U S A. 1997;94:4167–70.

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