Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia-Reference-Cited by-同舟云学术

Neuroinflammation increases GABAergic tone and impairs cognitive and motor function in hyperammonemia by increasing GAT-3 membrane expression. Reversal by sulforaphane by promoting M2 polarization of microglia

Published:2016-04-18 Issue:1 Volume:13 Page:
ISSN:1742-2094
Container-title:Journal of Neuroinflammation
language:en
Short-container-title:J Neuroinflammation

Author:

Hernandez-Rabaza Vicente,Cabrera-Pastor Andrea,Taoro-Gonzalez Lucas,Gonzalez-Usano Alba,Agusti Ana,Balzano Tiziano,Llansola Marta,Felipo Vicente

Funder

Ministerio de Ciencia e Innovación

Conselleria Educacion Generalitat Valenciana

European Regional Development Funds (ERDF)

Ministerio de Educacion Spain

Publisher

Springer Science and Business Media LLC

Subject

Cellular and Molecular Neuroscience,Neurology,Immunology,General Neuroscience

Link

http://link.springer.com/content/pdf/10.1186/s12974-016-0549-z

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3. Felipo V, Ordoño JF, Urios A, El Mlili N, Giménez-Garzó C, Aguado C, et al. Patients with minimal hepatic encephalopathy show impaired mismatch negativity correlating with reduced performance in attention tests. Hepatology. 2012;5(2):530–9.

4. Felipo V. Hepatic encephalopathy: effects of liver failure on brain function. Nat Rev Neurosci. 2013;14(12):851–8.

5. Shawcross DL, Davies NA, Williams R, Jalan R. Systemic inflammatory response exacerbates the neuropsychological effects of induced hyperammonemia in cirrhosis. J Hepatol. 2004;40(2):247–54.

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