Chemical constituents from the medicinal herb-derived fungus Chaetomium globosum Km1226

Author:

Chang Chia-Hao,Hsiao George,Wang Shih-Wei,Yen Juei-Yu,Huang Shu-Jung,Chi Wei-Chiung,Lee Tzong-HueiORCID

Abstract

Abstract Background Endophytic fungi have proven to be a rich source of novel natural products with a wide-array of biological activities and higher levels of structural diversity. Results Chemical investigation on the liquid- and solid-state fermented products of Chaetomium globosum Km1226 isolated from the littoral medicinal herb Atriplex maximowicziana Makino resulted in the isolation of compounds 114. Their structures were determined by spectroscopic analysis as three previously undescribed C13-polyketides, namely aureonitol C (1), mollipilins G (2), and H (3), along with eleven known compounds 414. Among these, mollipilin A (5) exhibited significant nitric oxide production inhibitory activity in LPS-induced BV-2 microglial cells with an IC50 value of 0.7 ± 0.1 µM, and chaetoglobosin D (10) displayed potent anti-angiogenesis property in human endothelial progenitor cells (EPCs) with an IC50 value of 0.8 ± 0.3 µM. Conclusions Three previously unreported compounds 13 were isolated and identified. Mollipilin A (5) and chaetoglobosin D (10) could possibly be developed as anti-inflammatory and anti-angiogenic lead drugs, respectively.

Funder

Ministry of Science and Technology of Taiwan

Publisher

Springer Science and Business Media LLC

Subject

Plant Science

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