Abstract
Abstract
Background
To investigate the efficacy of Qingre Lishi Decoction(QLRD), in the treatment of acute gouty arthritis, and its influence on the expression levels of inflammatory factor nucleotide-binding oligomerization domain-like receptor(NALP 3) in patients.
Methods
A total of 78 patients with acute gouty arthritis admitted to our hospital were randomly divided into the control group and the observation group, with 39 cases in each group. The control group was given basic treatment and colchicine tablets, and the observation group was given “heat-clearing and diuresis-promoting” prescription for intervention treatment. The main symptom score, treatment effective rate and laboratory indexes of the two groups were compared 7 days after treatment.
Results
After treatment, the scores of joint redness, hot pain, joint flexion and extension disorder, oliguria and constipation were improved in both groups, and the improvement degree in observation group was higher than that in control group (P < 0.05); the clinical effective rate in the observation group (94.87%) was higher than that in the control group (76.92%). The serum uric acid (UA), erythrocyte sedimentation rate (ESR), interleukin-1β (IL-1β) and NALP3 showed a decreasing trend, and the decrease degree of each index in observation group was higher than that in control group (P < 0.05).
Conclusion
The “heat-clearing and diuresis-promoting” prescription for intervention treatment can effectively improve the clinical symptoms of patients with acute gouty arthritis and reduce the level of inflammatory factor NALP3, maintaining remarkable effect.
Publisher
Springer Science and Business Media LLC
Subject
Orthopedics and Sports Medicine,Surgery
Reference16 articles.
1. Li Y, Piranavan P, Sundaresan D, Yood R. Clinical characteristics of early-onset gout in outpatient setting. ACR Open Rheumatol. 2019;1(7):397–402.
2. Li QH, Liang JJ, Chen LX, Mo YQ, Wei XN, Zheng DH, Dai L. Clinical characteristics and renal uric acid excretion in early-onset gout patients. Zhonghua Nei Ke Za Zhi. 2018;57(3):185–90.
3. PérezRuiz F, Richette P, Stack AG, Karra Gurunath R, Garcíade Yébenes MJ, Carmona L. Failure to reach uric acid target of < 0.36 mmol/L in hyperuricaemia of gout is associated with elevated total and cardiovascular mortality. RMD Open. 2019;5(2):e001015.
4. Li YJ, Perng WT, Tseng KY, Wang YH, Wei JC. Association of gout medications and risk of cataract: a population-based case-control study. QJM. 2019;112(11):841–6.
5. Angelidis C, Kotsialou Z, Kossyvakis C, Vrettou AR, Zacharoulis A, Kolokathis F, Kekeris V, Giannopoulos G. Colchicine pharmacokinetics and mechanism of action. Curr Pharm Des. 2018;24(6):659–63.
Cited by
2 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献