Author:
Koh Kirsten P,Fassett Robert G,Sharman James E,Coombes Jeff S,Williams Andrew D
Abstract
Abstract
Background
Exercise training in hemodialysis patients improves fitness, physical function, quality of life and markers of cardiovascular disease such as arterial stiffness. The majority of trials investigating this area have used supervised exercise training during dialysis (intradialytic), which may not be feasible for some renal units. The aim of this trial is to compare the effects of supervised intradialytic with unsupervised home-based exercise training on physical function and arterial stiffness.
Methods and design
This is a randomised, controlled clinical trial. A total of 72 hemodialysis patients will be randomised to receive either six months of intradialytic exercise training, home-based exercise training or usual care. Intradialytic patients will undergo three training sessions per week on a cycle ergometer and home-based patients will be provided with a walking program to achieve the same weekly physical activity. Primary outcome measures are six-minute walk distance (6 MWD) and aortic pulse wave velocity (PWV). Secondary outcome measures include augmentation index, peripheral and central blood pressures, physical activity and self-reported health. Measures will be made at baseline, three and six months.
Discussion
The results of this study will help determine the efficacy of home-based exercise training in hemodialysis patients. This may assist in developing exercise guidelines specific for these patients.
Trial Registration
ACTRN12608000247370
Publisher
Springer Science and Business Media LLC
Reference30 articles.
1. Johansen KL: Exercise in the end-stage renal disease population. J Am Soc Nephrol. 2007, 18 (6): 1845-1854. 10.1681/ASN.2007010009.
2. Miller BW, Cress CL, Johnson ME, Nichols DH, Schnitzler MA: Exercise during hemodialysis decreases the use of antihypertensive medications. Am J Kidney Dis. 2002, 39 (4): 828-833. 10.1053/ajkd.2002.32004.
3. Zaluska A, Zaluska WT, Bednarek-Skublewska A, Ksiazek A: Nutrition and hydration status improve with exercise training using stationary cycling during hemodialysis (HD) in patients with end-stage renal disease (ESRD). Ann Univ Mariae Curie Sklodowska [Med]. 2002, 57 (2): 342-346.
4. Goldberg AP, Geltman EM, Gavin JR, Carney RM, Hagberg JM, Delmez JA, Naumovich A, Oldfield MH, Harter HR: Exercise training reduces coronary risk and effectively rehabilitates hemodialysis patients. Nephron. 1986, 42 (4): 311-316. 10.1159/000183694.
5. Painter PL, Nelson-Worel JN, Hill MM, Thornbery DR, Shelp WR, Harrington AR, Weinstein AB: Effects of exercise training during hemodialysis. Nephron. 1986, 43 (2): 87-92. 10.1159/000183805.
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献