Author:
Kwon Ji-Hye,Park Jungchan,Lee Seung-Hwa,Hyun Cheol Won,Kim Jihoon,Yang Kwangmo,Min Jeong Jin,Lee Jong Hwan,Lee Sangmin Maria,Choi Jin-ho,Lee Sang-Chol,Gwon Hyeon-Cheol,Her Sukyoung,Kim Kyunga,Ahn Joonghyun
Abstract
Abstract
Background
Myocardial injury after non-cardiac surgery (MINS) has recently been accepted as a predictor of mortality. However, sex differences in the incidence of MINS and survival thereafter are not fully understood. This study aimed to compare the incidence of MINS and mortality among male and female patients.
Methods
This single-center study was conducted using the database of a large tertiary referral hospital. Consecutive patients with cardiac troponin (cTn) detected within 30 days after non-cardiac surgery performed between January 2010 and June 2019 were grouped according to sex. The incidence of MINS and mortality of patients with MINS were compared between men and women.
Results
Of the 33,311 patients, 18,546 (55.7%) were men and 14,765 (44.3%) were women. In a multivariable analysis, women showed a significantly lower incidence of MINS than did men (17.9% vs. 14.2%; odds ratio, 0.76; 95% confidence interval [CI], 0.71–0.81; P < 0.001). In patients with MINS, the propensity-score-matched analysis showed that 30-day mortality did not differ according to sex, but mortality in females was significantly lower than that in males during the overall follow-up (33.0% vs. 25.7%; hazard ratio, 0.75; 95% CI, 0.66–0.84; P < 0.001).
Conclusion
The incidence of MINS was lower in women than in men. In patients with MINS, female sex may be associated with a survival benefit. Further studies are needed to confirm these findings.
Publisher
Springer Science and Business Media LLC
Cited by
1 articles.
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