Author:
Qiu Fang,Wang Yanmei,Du Yunbo,Zeng Changchun,Liu Yuqiang,Pan Haobo,Ke Changneng
Abstract
AbstractCurcumin has anti-inflammatory, antioxidant, and anticancer effects and is used to treat diseases such as dermatological diseases, infection, stress, depression, and anxiety. J147, an analogue of curcumin, is designed and synthesized with better stability and bioavailability. Accumulating evidence demonstrates the potential role of J147 in the prevention and treatment of Alzheimer’s disease, diabetic neuropathy, ischemic stroke, depression, anxiety, and fatty liver disease. In this narrative review, we summarized the background and biochemical properties of J147 and discussed the role and mechanism of J147 in different diseases. Overall, the mechanical attributes of J147 connote it as a potential target for the prevention and treatment of neurological diseases.
Funder
Science and Technology Project of Shenzhen Municipality of China
Guangdong Basic and Applied Basic Research Foundation of China
the Medical Institution Foundation of Shenzhen Longhua District.
the China Postdoctoral Science Foundation
National Natural Science Foundation of China
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Medicine
Cited by
2 articles.
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