Author:
Zhu Zhuang,Muhammad Bilal,Du Bo,Gu Ning,Meng Tian-Yue,Kan Shu,Mu Ying-Feng,Cheng Yan-Bo,Zhu Shi-Guang,Geng De-Qin
Abstract
AbstractObjectiveFew studies correlated n-terminal pro-brain natriuretic peptide (NT-proBNP) with early neurological deterioration (END) and prognosis of acute ischaemic stroke (AIS) patients with rt-PA intravenous thrombolysis. Therefore this study aimed to investigate the relationship between NT-proBNP and END, and prognosis after intravenous thrombolysis in patients with AIS.MethodsA total of 325 patients with AIS were enrolled. We performed the natural logarithm transformation on the NT-proBNP [ln(NT-proBNP)]. Univariate and multivariate logistic regression analyses were performed to assess the relationship between ln(NT-proBNP) and END, and prognosis and receiver operating characteristic (ROC) curves were used to show the sensitivity and specificity of NT-proBNP.ResultsAfter thrombolysis, among 325 patients with AIS, 43 patients (13.2%) developed END. In addition, three months follow-up showed a poor prognosis in 98 cases (30.2%) and a good prognosis in 227 cases (69.8%). Multivariate logistic regression analysis showed that ln(NT-proBNP) was an independent risk factor for END (OR = 1.450,95%CI:1.072 ~ 1.963,P = 0.016) and poor prognosis at three months follow-up (OR = 1.767, 95%CI: 1.347 ~ 2.317,P < 0.001) respectively. According to ROC curve analysis, ln(NT-proBNP) (AUC 0.735, 95%CI: 0.674 ~0.796,P < 0.001) had a good predictive value for poor prognosis, with a predictive value of 5.12 and sensitivity and specificity of 79.59% and 60.35% respectively. When combined with NIHSS to predict END(AUC 0.718, 95%CI: 0.631 ~ 0.805,P < 0.001) and poor prognosis(AUC 0.780, 95%CI: 0.724 ~ 0.836,P < 0.001), the predictive value of the model is further improved.ConclusionNT-proBNP is independently associated with END and poor prognosis in patients with AIS following intravenous thrombolysis and has a particular predictive value for END and poor prognosis.
Funder
Xuzhou Promoting Science and Technology Innovation Project
National Health Commission Brain Prevention Committee "Research and Promotion Project of Appropriate Technology Intervention for High-risk Groups of Stroke in China"
Publisher
Springer Science and Business Media LLC
Subject
Neurology (clinical),General Medicine
Cited by
1 articles.
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