Author:
Kubo Shin-ichiro,Matsubara Tomoyasu,Taguchi Takeshi,Sengoku Renpei,Takeuchi Atsuko,Saito Yuko
Abstract
Abstract
Background
Late-stage Parkinson’s disease (PD) often presents with neuropsychiatric symptoms such as dementia, psychosis, excessive daytime sleepiness, apathy, depression, and anxiety. However, neuropsychiatric symptoms are the cardinal features of Creutzfeldt–Jakob disease (CJD), raising the possibility that CJD may be an overlooked condition when it accompanies late-stage PD.
Case presentation
We describe a female autopsy case of PD with a typical clinical course of 17 years, in which CJD overlapped with PD during the final year of the patient’s life. The patient died aged 85 years. Neuropathological features included widespread Lewy body-related α-synucleinopathy predominantly in the brainstem and limbic system, as well as the typical pathology of methionine/methionine type 1 CJD in the brain.
Conclusions
Our case demonstrates the clinicopathological co-occurrence of PD and CJD in a sporadic patient. The possibility of mixed pathology, including prion pathology, should be taken into account when neuropsychiatric symptoms are noted during the disease course of PD.
Funder
Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science
Ministry of Health, Labour and Welfare
Publisher
Springer Science and Business Media LLC
Subject
Clinical Neurology,General Medicine
Cited by
1 articles.
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